• 348 Citations
  • 10 h-Index
20042020

Research output per year

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Personal profile

Research Biography

Dr Adeline Lau is a Research Fellow in Neurometabolic Disorders and joined the Flinders Health and Medical Research Institute (FHMRI) in January 2020. After completing her BBiotech (Hons) at Flinders University, she joined Associate Professor Kim Hemsley’s Childhood Dementia Research Group where she has been investigating novel therapeutic approaches for the treatment of early-onset neurodegenerative lysosomal storage disorders. As part of her PhD studies, Adeline was a visiting scientist in the laboratory of Dr Eric Kremer (Institut de Génétique Moléculaire de Montpellier, France), where she generated viral gene therapy vectors to examine the clinical efficacy of this approach using a mouse model of Sanfilippo syndrome using behavioural phenotyping, biochemical and histological techniques. Adeline’s research has evaluated therapies such as bone marrow transplantation, stem cell therapy, AAV and non-human adenoviral gene transfer and has more recently focussed on developing small molecule drugs such as pharmacological chaperones and heparan sulfate biosynthesis inhibitors.

Education/Academic qualification

PhD

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Research Output

  • 348 Citations
  • 10 h-Index
  • 16 Article
  • 2 Chapter
  • 2 Review article
  • 1 Comment/debate

AAVrh10 Vector Corrects Disease Pathology in MPS IIIA Mice and Achieves Widespread Distribution of SGSH in Large Animal Brains

Hocquemiller, M., Hemsley, K. M., Douglass, M. L., Tamang, S. J., Neumann, D., King, B. M., Beard, H., Trim, P. J., Winner, L. K., Lau, A. A., Snel, M. F., Gomila, C., Ausseil, J., Mei, X., Giersch, L., Plavsic, M. & Laufer, R., 12 Jun 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 174-187 14 p.

Research output: Contribution to journalArticle

Open Access
File
  • 2 Citations (Scopus)
    5 Downloads (Pure)

    Lysosomal Dysregulation in the Murine AppNL-G-F/NL-G-F Model of Alzheimer's Disease

    Whyte, L. S., Hassiotis, S., Hattersley, K. J., Hemsley, K. M., Hopwood, J. J., Lau, A. A. & Sargeant, T. J., 1 Mar 2020, In : Neuroscience. 429, p. 143-155 13 p.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    Canine adenoviral vector-mediated gene transfer to the guinea pig brain

    Lau, A. A., Hopwood, J. J. & Hemsley, K. M., Sep 2019, In : Gene Reports. 16, 5 p., 100432.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Synthetic Disaccharide Standards Enable Quantitative Analysis of Stored Heparan Sulfate in MPS IIIA Murine Brain Regions

    He, Q. Q., Trim, P. J., Lau, A. A., King, B. M., Hopwood, J. J., Hemsley, K. M., Snel, M. F. & Ferro, V., 21 Aug 2019, In : ACS Chemical Neuroscience. 10, 8, p. 3847-3858 12 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    MPS-IIIA mice acquire autistic behaviours with age

    Lau, A. A., Tamang, S. J. & Hemsley, K. M., Jul 2018, In : JOURNAL OF INHERITED METABOLIC DISEASE. 41, 4, p. 669-677 9 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)