Research output per year
Research output per year
Personal profile
Research Biography
Dr Adeline Lau is a Senior Research Fellow in Neurometabolic Disorders and joined the Flinders Health and Medical Research Institute (FHMRI) in 2020. After completing her BBiotech (Hons) at Flinders University, she joined the Childhood Dementia Research Group where she has been investigating novel therapeutic approaches for the treatment of early-onset neurodegenerative lysosomal storage disorders. Adeline’s research has evaluated therapies such as bone marrow transplantation, stem cell therapy, AAV and non-human adenoviral gene transfer and has more recently focussed on developing small molecule drugs such as pharmacological chaperones and heparan sulfate biosynthesis inhibitors.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD
Supervision
- Registered
Research Areas
- Molecular biosciences
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Collaborations and top research areas from the last five years
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Evaluation of neuroretina following i.v. or intra-CSF AAV9 gene replacement in mice with MPS IIIA, a childhood dementia
Beard, H., Winner, L., Shoubridge, A., Parkinson-Lawrence, E., Lau, A. A., Mubarokah, S. N., Lance, T.-R., King, B., Scott, W., Snel, M. F., Trim, P. J. & Hemsley, K. M., Aug 2024, In: CNS Neuroscience and Therapeutics. 30, 8, 13 p., e14919.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Downloads (Pure) -
Filipin complex-reactive brain lesions: A cautionary tale
Lau, A. A., Trim, P. J., King, B. M., Hassiotis, S., Hung, Y. H., Bush, A. I., Snel, M. F. & Hemsley, K. M., Feb 2024, In: Neuropathology and Applied Neurobiology. 50, 1, 8 p., e12950.Research output: Contribution to journal › Article › peer-review
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Photobiomodulation in the infrared spectrum reverses the expansion of circulating natural killer cells and brain microglial activation in Sanfilippo mice
Lau, A. A., Jin, K., Beard, H., Windram, T., Xie, K., O’Brien, J. A., Neumann, D., King, B. M., Snel, M. F., Trim, P. J., Mitrofanis, J., Hemsley, K. M. & Austin, P. J., Sept 2024, In: Journal of Neurochemistry. 168, 9, p. 2791-2813 23 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Downloads (Pure) -
Substrate reduction therapy in a Drosophila melanogaster model of Sanfilippo syndrome
Tan, S. L., Hewson, L. J., Mustaffar, N. F., He, Q. Q., Wimmer, N., Trim, P. J., King, B., Snel, M. F., Hemsley, K. M., Ferro, V., O'Keefe, L. V. & Lau, A. A., 28 Mar 2023, bioRxiv, Cold Spring Harbor Laboratory, 27 p.Research output: Working paper/Preprint › Preprint
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Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease
Whyte, L. S., Fourrier, C., Hassiotis, S., Lau, A. A., Trim, P. J., Hein, L. K., Hattersley, K. J., Bensalem, J., Hopwood, J. J., Hemsley, K. M. & Sargeant, T. J., Jun 2022, In: IBRO Neuroscience Reports. 12, p. 131-141 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)89 Downloads (Pure)