Research output per year
Research output per year
Personal profile
Research Biography
Dr Adeline Lau is a Senior Research Fellow in Neurometabolic Disorders and joined the Flinders Health and Medical Research Institute (FHMRI) in 2020. After completing her BBiotech (Hons) at Flinders University, she joined the Childhood Dementia Research Group where she has been investigating novel therapeutic approaches for the treatment of early-onset neurodegenerative lysosomal storage disorders. Adeline’s research has evaluated therapies such as bone marrow transplantation, stem cell therapy, AAV and non-human adenoviral gene transfer and has more recently focussed on developing small molecule drugs such as pharmacological chaperones and heparan sulfate biosynthesis inhibitors.
Education/Academic qualification
PhD
Supervision
- Registered
Research Areas
- Molecular biosciences
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Synthesis of a C-2 Functionalized l-Iduronic Acid Derivative as a Candidate Pharmacological Chaperone for MPS II (Hunter Syndrome)
Nagendra, V., Mohamed, S., See, N. W., Wimmer, N., Neumann, D., Trim, P. J., Snel, M., Brock, A. J., Clegg, J. K., Gandhi, N. S., Hemsley, K. M., Lau, A. A. & Ferro, V., 15 Jun 2026, In: Chemistry - An Asian Journal. 21, 11, 15 p., e70823.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Cognitive impairment and progressive neuroinflammation in mucopolysaccharidosis IIIA mice expressing the R245H Sgsh variant
Lau, A. A., Beard, H., Trim, P. J., King, B. M., Snel, M. F. & Hemsley, K. M., 25 May 2025, (Submitted) bioRxiv, Cold Spring Harbor Laboratory, 20 p.Research output: Working paper/Preprint › Preprint
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Efficient synthesis of fluorogenic substrates for mucopolysaccharidosis (MPS) IIIA and IIIB via aromatic α-glycosylation with thioglycosyl donors
Pan, Y., Doherty, G. G., Al Nahain, A., Wimmer, N., Lau, A. A., Hemsley, K. M. & Ferro, V., 14 Jul 2025, (E-pub ahead of print) In: Organic and Biomolecular Chemistry. 23, 26, p. 6446-6455 10 p.Research output: Contribution to journal › Article › peer-review
File1 Citation (Scopus)62 Downloads (Pure) -
Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome
Tan, S. L., Neumann, D., Trim, P. J., Hewson, L. J., Mustaffar, N. F., He, Q. Q., Wimmer, N., Snel, M. F., Ferro, V., O'Keefe, L. V., Hemsley, K. M. & Lau, A. A., Jun 2025, In: Molecular Genetics and Metabolism. 145, 2, 12 p., 109112.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)72 Downloads (Pure) -
Evaluation of neuroretina following i.v. or intra-CSF AAV9 gene replacement in mice with MPS IIIA, a childhood dementia
Beard, H., Winner, L., Shoubridge, A., Parkinson-Lawrence, E., Lau, A. A., Mubarokah, S. N., Lance, T.-R., King, B., Scott, W., Snel, M. F., Trim, P. J. & Hemsley, K. M., Aug 2024, In: CNS Neuroscience and Therapeutics. 30, 8, 13 p., e14919.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)100 Downloads (Pure)
Projects
- 2 Active
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Do zebrafish models of Morquio syndrome display skeletal phenotypes?
Barthelson, K. (Chief Investigator (Project Lead)), Lau, A. (Chief Investigator), Hemsley, K. (Chief Investigator), Smith, N. (Chief Investigator) & Smith, L. (Chief Investigator)
2/02/26 → 2/02/27
Project: Research
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Pre-clinical evaluation of NAL for treatment of childhood dementia
Hemsley, K. (Chief Investigator (Project Lead)), Smith, N. (Chief Investigator), Lau, A. (Chief Investigator), Elvidge, K. (Chief Investigator), O'Neill, C. (Chief Investigator), Platt, F. (Associate Investigator) & Fields, T. (Associate Investigator)
5/01/26 → 31/12/27
Project: Research