• 495 Citations
  • 11 h-Index
20092019

Research output per year

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Personal profile

Research Biography

Prior to my appointment as Senior Lecturer in Medical Biochemistry at Flinders University, I completed postdoctoral studies at the University of Wollongong and the University of Cambridge, UK. My research attempts to elucidate the relationship between protein misfolding and inflammation which are characteristics that are shared by a very large number of debilitating disorders including Alzheimer's disease, atherosclerosis, pre-eclampsia and arthritis.

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Research Output

  • 495 Citations
  • 11 h-Index
  • 11 Article
  • 2 Review article
  • 1 Chapter

Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide

Cater, J. H., Kumita, J. R., Abdallah, R. Z., Zhao, G., Bernardo-Gancedo, A., Henry, A., Winata, W., Chi, M., Grenyer, B. S. F., Townsend, M. L., Ranson, M., Buhimschi, C. S., Charnock-Jones, D. S., Dobson, C. M., Wilson, M. R., Buhimschi, I. A. & Wyatt, A. R., 26 Mar 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6101-6110 10 p.

Research output: Contribution to journalArticle

Open Access
File
  • 7 Citations (Scopus)
    3 Downloads (Pure)

    Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones

    Constantinescu, P., Brown, R. A., Wyatt, A. R., Ranson, M. & Wilson, M. R., Jul 2017, In : Journal of Biological Chemistry. 292, 35, p. 14425-14437 13 p.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins?

    Wyatt, A. R., Cater, J. H. & Ranson, M., Oct 2016, In : International Journal of Biochemistry and Cell Biology. 79, p. 113-117 5 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 10 Citations (Scopus)
    1 Downloads (Pure)

    Alpha-2-macroglobulin is acutely sensitive to freezing and lyophilization: Implications for structural and functional studies

    Wyatt, A. R., Kumita, J. R., Farrawell, N. E., Dobson, C. M. & Wilson, M. R., Jun 2015, In : PLoS One. 10, 6, 19 p., e0130036.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Citations (Scopus)

    Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin

    Wyatt, A. R., Kumita, J. R., Mifsud, R. W., Gooden, C. A., Wilson, M. R. & Dobson, C. M., 20 May 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. E2081-E2090 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 35 Citations (Scopus)