Research output per year
Research output per year
Personal profile
Research Biography
Prior to my appointment as Senior Lecturer in Medical Biochemistry at Flinders University, I completed postdoctoral studies at the University of Wollongong and the University of Cambridge, UK. My research attempts to elucidate the relationship between protein misfolding and inflammation which are characteristics that are shared by a very large number of debilitating disorders including Alzheimer's disease, atherosclerosis, pre-eclampsia and arthritis.
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A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone
Cater, J. H., Mañucat-Tan, N. B., Georgiou, D. K., Zhao, G., Buhimschi, I. A., Wyatt, A. R. & Ranson, M., Apr 2022, In: Cells. 11, 7, 15 p., 1152.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma
Mañucat-Tan, N., Zeineddine Abdallah, R., Kaur, H., Saviane, D., Wilson, M. R. & Wyatt, A., Apr 2021, In: Redox Biology. 40, p. 101847 10 p., 101847.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)15 Downloads (Pure) -
Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator
Cater, J. H., Wilson, M. R. & Wyatt, A. R., 22 Jul 2019, In: Oxidative Medicine and Cellular Longevity. 2019, 9 p., 5410657.Research output: Contribution to journal › Review article › peer-review
Open AccessFile31 Citations (Scopus)6 Downloads (Pure) -
Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide
Cater, J. H., Kumita, J. R., Abdallah, R. Z., Zhao, G., Bernardo-Gancedo, A., Henry, A., Winata, W., Chi, M., Grenyer, B. S. F., Townsend, M. L., Ranson, M., Buhimschi, C. S., Charnock-Jones, D. S., Dobson, C. M., Wilson, M. R., Buhimschi, I. A. & Wyatt, A. R., 26 Mar 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6101-6110 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Citations (Scopus)12 Downloads (Pure) -
Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones
Constantinescu, P., Brown, R. A., Wyatt, A. R., Ranson, M. & Wilson, M. R., 1 Sep 2017, In: Journal of Biological Chemistry. 292, 35, p. 14425-14437 13 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus)