Personal profile
Research Biography
I am passionate about engaging with industry and clinicians to resolve knowledge gaps regarding the impact of life stage, environmental factors and disease on the activity of proteins that influence drug exposure and response. My research focusses on using this knowledge to inform safe and effective use of medicines to achieve optimal therapeutic outcomes for patients. I strive to be a role model for courage, integrity and perseverence to my two sons.
I was awarded a PhD in Clinical Pharmacology from Flinders University in 2009. Following a 2 year post-doctoral position in the Miners’ Drug Metabolism laboratory, in 2011 I was appointed to my current academic position in the College of Medicine and Public Health. Now Associate Professor, I lead a dynamic team of researchers at the forefront of advancing extracellular vesicle (EVs) isolation and analysis platforms for use with biospecimens. My team are world leaders in the isolation and characterisation of tissue specific EVs from blood and work closely with industry and clinicians to apply this technology to improve patient outcomes by enhancing drug efficacy and minimising harms.
I teach the principles of pharmacology and therapeutics to a spectrum of medical and health professionals including doctors, nurse prescribers, paramedics and medical scientists.
Supervised Students Successes
- Nov 2019 Ms Lauren Newman - 2019 Drug Disposition and Response Prize
- Nov 2019 Mr Warit Ruanglertboon - 2019 British Journal of Clinical Pharmacology Prize
- Aug 2019 Ms Asha Kapetas - 2019 Simcyp Most Informative Scientific Report
- Dec 2015 Dr Madelé van Dyk - 2015 ASCEPT Drug Disposition and Response Prize
Completed Supervisions
- Pharmacology (1)
Supervision
- Registered
Research Areas
- Medical biosciences
Supervisory Interests
- Clinical pharmacokinetics
- Drug metabolising enzymes
- Drug-drug interactions
- Extracellular Vesicles
- Predictive Biomarkers
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 9 Industry, Innovation, and Infrastructure -
SDG 10 Reduced Inequalities -
SDG 17 Partnerships for the Goals
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From Endogenous Compounds as Biomarkers to Plasma-Derived Nanovesicles as Liquid Biopsy: Has the Golden Age of Translational Pharmacokinetics-Absorption, Distribution, Metabolism, Excretion-Drug–Drug Interaction Science Finally Arrived?
Rodrigues, D. & Rowland, A., Jun 2019, In: Clinical Pharmacology and Therapeutics. 105, 6, p. 1407-1420 14 p.Research output: Contribution to journal › Review article › peer-review
70 Citations (Scopus) -
Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure
Rowland, A., Ruanglertboon, W., Van Dyk, M., Wijayakumara, D. D., Wood, L. S., Meech, R., Mackenzie, P. I., Rodrigues, A. D., Marshall, J. C. & Sorich, M. J., 1 Jan 2019, In: British Journal of Clinical Pharmacology. 85, 1, p. 216-226 11 p.Research output: Contribution to journal › Article › peer-review
Open Access71 Citations (Scopus) -
Exploring the Use of Serum‐Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Hepatic Cytochromes P450 and Organic Anion Transporting Polypeptides
David Rodrigues, A., Van Dyk, M., Sorich, M., Fahmy, A., Useckaite, Z., Newman, L. A., Kapetas, A. J., Mounzer, R., Wood, L. S., Johnson, J. G. & Rowland, A., Jul 2021, In: Clinical Pharmacology and Therapeutics. 110, 1, p. 248-258 11 p.Research output: Contribution to journal › Article › peer-review
58 Citations (Scopus) -
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio , D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu , Q.-L., Hill , A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R. & Ochiya, T. & 54 others, , Feb 2024, In: Journal of extracellular vesicles. 13, 2, 84 p., e12404.Research output: Contribution to journal › Article › peer-review
Open AccessFile3208 Citations (Scopus)742 Downloads (Pure) -
Selective Isolation of Liver-Derived Extracellular Vesicles Redefines Performance of miRNA Biomarkers for Non-Alcoholic Fatty Liver Disease
Newman, L. A., Useckaite, Z., Johnson, J., Sorich, M. J., Hopkins, A. M. & Rowland, A., Jan 2022, In: Biomedicines. 10, 1, 16 p., 195.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)248 Downloads (Pure)
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Mechanistic Insights into LNP–mRNA Uptake and Extracellular Vesicle Redistribution
Rowland, A. (Chief Investigator (Project Lead)) & Hopkins, A. (Chief Investigator)
1/04/26 → 1/04/30
Project: Research
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Unlocking Cellular Mechanisms to Advance Next-Generation mRNA Therapeutics
Rowland, A. (Chief Investigator (Project Lead)) & Hopkins, A. (Chief Investigator)
23/03/26 → 1/04/30
Project: Research
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Tissue Specific Liquid Biopsy to Enhance Medication Efficacy and Safety
Rowland, A. (Chief Investigator (Project Lead)), Guchelaar, H. J. (Chief Investigator), Stocker, S. (Chief Investigator), McLachlan, A. J. (Chief Investigator), Logan, J. M. (Chief Investigator), Hopkins, A. (Associate Investigator) & Rowland, A. (Associate Investigator)
1/01/26 → 31/12/28
Project: Research
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A Comprehensive ADME Genomic Profile to Enhance Safety and Reduce Medicine Harms
Rowland, A. (Chief Investigator (Project Lead)), Westley, I. (Chief Investigator), Kichenadasse, G. (Chief Investigator), Sorich, M. (Chief Investigator), Newman, L. (Chief Investigator), Ross, D. (Chief Investigator), Branford, S. (Chief Investigator), Scott, H. (Chief Investigator), Hopkins, A. (Chief Investigator), Karapetis, C. (Chief Investigator), Guchelaar, H. J. (Chief Investigator), To, T. (Chief Investigator), Karnon, J. (Chief Investigator) & Haseloff, M. (Associate Investigator)
1/06/25 → 31/05/28
Project: Research
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Riding for Wellness: Quantitative Assessment of Cycling’s Physical and Psychological Benefits in Patients with Cancer
Hopkins, A. (Chief Investigator (Project Lead)), Miegel, R. (Chief Investigator), Haseloff, M. (Chief Investigator), Modi, N. (Chief Investigator), Karapetis, C. (Associate Investigator), Rowland, A. (Associate Investigator) & Wallen, M. (Associate Investigator)
1/03/25 → 28/02/27
Project: Research