• 645 Citations
  • 15 h-Index
19992020

Research output per year

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Personal profile

Research Biography

Dr Claire Jessup is a medical researcher interested in harnessing the power of the immune system to modulate disease. Specific research projects examine the molecular activation of immune cells involved in the rejection of transplants and the development of autoimmune diseases (e.g. Type 1 diabetes).

Dr Jessup heads the iMOD and Islet Biology group within the College of Medicine and Public Health. Her laboratory utilises techniques including flow cytometry, gene therapy, pancreatic islet isolation, in vitro beta cell and immune assays, confocal microscopy and islet transplantation and diabetes models.

Recent research projects include:

  • Modulation of T lymphocyte activation during Type 1 diabetes and islet transplant rejection
  • Examining the role of cell surface and intracellular molecules in pancreatic islet function and beta cell survival (Cx36, RCAN1, SK1) 
  • Investigating the interplay between vascular and endocrine cell types during islet transplantation

In addition to her research role, Dr Jessup teaches Anatomy and Histology topics within the MD course and supervises PhD research students.

Dr Jessup acknowledges support from generous funding bodies including NHMRC, Diabetes Australia, Channel 7 Children's Research Foundation, FMC Foundation and Department of Further Education, Employment, Science and Technology.

Research Interests

My group's research programme is focussed on harnessing the power of the immune system to modulate complex cellular interactions including those that occur during diabetes development, transplant rejection and oncogenesis. Our work demonstrated the potential of a cellular cotherapy (endothelial progenitor cells) in improving islet transplantation outcomes. We continue to utilize cellular and molecular techniques, diabetes and transplantation models, and confocal microscopy to probe the intricate interactions between insulin-producing beta cells and other cell types within the pancreatic islet. More broadly, projects strive to dissect the interplay between tissue microenvironment, vasculature and the immune system and examine how immunomodulation may be applied in the clinic.

Education/Academic qualification

PhD, Flinders University

Award Date: 1 Dec 2005

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Research Output

  • Cellular regulation of peripheral serotonin

    Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F. & Keating, D. J., 2019, Serotonin: The Mediator that Spans Evolution. Pilowsky, P. (ed.). Academic Press, p. 137-153 17 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • The gut microbiome regulates host glucose homeostasis via peripheral serotonin

    Martin, A. M., Yabut, J. M., Choo, J. M., Page, A. J., Sun, E. W., Jessup, C. F., Wesselingh, S. L., Khan, W. I., Rogers, G. B., Steinberg, G. R. & Keating, D. J., 1 Oct 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 40, p. 19802-19804 3 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    2 Downloads (Pure)

    Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis

    Rotter, D., Peiris, H., Grinsfelder, D., Martin, A., Burchfield, J., Parra, V., Hull, C., Morales, C., Jessup, C., Matusica, D., Parks, B., Lusis, A., Nguyen, N., Oh, M., Iyoke, I., Jakkampudi, T., McMillan, D., Sadek, H., Watt, M., Gupta, R. & 3 others, Pritchard, M., Keating, D. & Rothermel, B., 2018, In : EMBO REPORTS. 19, 12, 19 p., e44706.

    Research output: Contribution to journalArticle

  • 7 Citations (Scopus)

    Local Sphingosine Kinase 1 Activity Improves Islet Transplantation

    Rojas-Canales, D., Penko, D., Myo Min, K., Parham, K., Peiris, G., Haberberger, R., Pitson, S., Drogemuller, C., Keating, D., Grey, S., Coates, P., Bonder, C. & Jessup, C., 2017, In : Diabetes. 66, 5, p. 1301-1311 11 p.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)