Dr Craig Wallington-Beddoe

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20032020

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Personal profile

Research Biography

Dr Wallington-Beddoe is a Consultant Clinical Haematologist at Flinders Medical Centre and Senior Research Fellow at Flinders University. He is Director of Haematology Clinical Trials for Southern Adelaide Local Health Network where he is the Principal Investigator for several clinical trials for patients with the aggressive blood cancer multiple myeloma. Being a cancer biologist and clinical haematologist, Dr Wallington-Beddoe seeks to translate research findings to the clinic, focusing on novel biomarkers and therapeutic strategies for multiple myeloma.

After completing specialist medical qualifications (FRACP/FRCPA) in the discipline of haematology at Westmead Hospital in Sydney, Dr Wallington-Beddoe undertook PhD studies at The University of Sydney. His work sought to investigate novel therapeutic strategies for acute lymphoblastic leukaemia and resulted in several high impact publications and numerous national and international conference presentations. In recognition of this work, Dr Wallington-Beddoe was awarded the 2012 Haematology Society of Australia and New Zealand Albert Baikie Memorial Medal and New Investigator Grant. Supported by a NHMRC Peter Doherty Post-Doctoral Research Fellowship, he relocated to Adelaide in 2013 to undertake post-doctoral research at the Centre for Cancer Biology, University of South Australia. This period of research elucidated how certain sphingolipid enzymes can be targeted in multiple myeloma to enhance responses to proteasome inhibitors, an important class of drugs for this cancer, resulting in several key publications.

Dr Wallington-Beddoe now heads the Flinders University division of an integrated translational multiple myeloma research program in tandem with the Centre for Cancer Biology, University of South Australia, which aims to maximise clinical and research outcomes for this blood cancer.

Research Interests

Haematological malignancies with a particular focus on multiple myeloma. My research seeks to manipulate endoplasmic reticulum stress in myeloma cells to enhance the cytotoxic effects of proteasome inhibitors and other novel agents, particularly in the setting of relapsed or refractory disease. More recently, I am investigating the role of adhesion proteins on myeloma cells with the aim of therapeutically targeting both the bone marrow microenvironment and the malignant cell itself.

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