Research output per year
Research output per year
Personal profile
Research Biography
My research interests are focused on the gut-brain axis and understanding how changes in luminal content such as food intake, long term dietary changes, enteric viruses and bacteria, and the gut microbiota are associated with a myriad of conditions and diseases. Specifically, my research is mainly focused on understanding how gut sensing cells, enteroendocrine cells, interact with and respond to their local gut environment, how they signal to the brain in response to changes in this environment, and how higher order bodily functions are altered by this gut-brain pathway.
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Collaborations and top research areas from the last five years
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Alterations in GLP-1 and PYY release with aging and body mass in the human gut
Jones, L. A., Sun, E. W., Lumsden, A. L., Thorpe, D. W., Peterson, R. A., De Fontgalland, D., Sposato, L., Rabbitt, P., Hollington, P., Wattchow, D. A. & Keating, D. J., 1 Dec 2023, In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 578, 6 p., 112072.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)82 Downloads (Pure) -
Single-cell gene expression links SARS-CoV-2 infection and gut serotonin
Martin, A. M., Roach, M., Jones, L. A., Thorpe, D., Coleman, R. A., Allman, C., Edwards, R. & Keating, D. J., Jul 2023, In: Gut. 72, 7, p. 1430-1431 2 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile3 Citations (Scopus)68 Downloads (Pure) -
Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
Ye, L., Bae, M., Cassilly, C. D., Jabba, S. V., Thorpe, D. W., Martin, A. M., Lu, H.-Y., Wang, J., Thompson, J. D., Lickwar, C. R., Poss, K. D., Keating, D. J., Jordt, S.-E., Clardy, J., Liddle, R. A. & Rawls, J. F., 10 Feb 2021, In: Cell Host and Microbe. 29, 2, p. 179-196.e9Research output: Contribution to journal › Article › peer-review
167 Citations (Scopus) -
Irinotecan-Induced Mucositis Is Associated with Goblet Cell Dysregulation and Neural Cell Damage in a Tumour Bearing DA Rat Model
Thorpe, D., Butler, R., Sultani, M., Vanhoecke, B. & Stringer, A., Apr 2020, In: Pathology and Oncology Research. 26, 2, p. 955-965 11 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy
The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASC/ISOO), 1 Oct 2020, In: Cancer. 126, 19, p. 4423-4431 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile379 Citations (Scopus)39 Downloads (Pure)