Personal profile
Research Biography
My research interests are focused on the gut-brain axis and understanding how changes in luminal content such as food intake, long term dietary changes, enteric viruses and bacteria, and the gut microbiota are associated with a myriad of conditions and diseases. Specifically, my research is mainly focused on understanding how gut sensing cells, enteroendocrine cells, interact with and respond to their local gut environment, how they signal to the brain in response to changes in this environment, and how higher order bodily functions are altered by this gut-brain pathway.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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The mood stabilizer lithium alters behaviour and physiology via the gut brain axis.
Thorpe, D. W., Ootsuka, Y., Peterson, R. A., Jones, L. A., Humenick, A., Martin, A. M., Zivkovic, J., Sakaguchi, J., McArdle, J., Ittner, A., Brookes, S. J., Habib, A., Sirimaharaj, R., Tawodros, Y., Roach, M., Edwards, R., Clevers, H., Beumer, J., Puschof, J. & Wei, L. & 9 others, , 27 Jan 2026, (Submitted) bioRxiv, Cold Spring Harbor Laboratory, p. 2026.01.26.701868, 36 p.Research output: Working paper/Preprint › Preprint
File11 Downloads (Pure) -
The Neuroepithelial Landscape of Enterochromaffin Cells Varies Across Gastrointestinal Location
Jones, L. A., Coleman, R. A., Allman, C., Humenick, A., Martin, A. M., Thorpe, D. W., Eyre, N. S. & Keating, D. J., Jan 2026, In: Neurogastroenterology and Motility. 38, 1, 9 p., e70221.Research output: Contribution to journal › Article › peer-review
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The role of peripheral serotonin in SARS-CoV-2 infectivity, COVID-19 treatment and long COVID
Thorpe, D. W., Jones, L. A., Martin, A. M., Coleman, R. A., Allman, C., Peterson, R. A. & Keating, D. J., Apr 2026, In: Immunology and Cell Biology. 104, 4, p. 368-376 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Alterations in GLP-1 and PYY release with aging and body mass in the human gut
Jones, L. A., Sun, E. W., Lumsden, A. L., Thorpe, D. W., Peterson, R. A., De Fontgalland, D., Sposato, L., Rabbitt, P., Hollington, P., Wattchow, D. A. & Keating, D. J., 1 Dec 2023, In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 578, 6 p., 112072.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)114 Downloads (Pure) -
How space dust settles our mind: discovery of the cell and receptor target of the mood stabiliser lithium
Thorpe, D., Peterson, R., Humenick, A., Ootsuka, Y., Blessing, W. & Keating, D., Dec 2023. 1 p.Research output: Contribution to conference › Abstract