My research aims to improve understanding of obstructive sleep apnoea (OSA) and respiratory disease pathophysiology, identify novel therapeutic targets, and develop new-targeted therapies. To do this, I lead a comprehensive translational research program. My team uses a variety of experimental approaches to measure upper airway neuromuscular control and respiratory mechanics in humans to advance knowledge of basic mechanisms through to multicentre clinical trials to test new therapies. I am most well-known for my respiratory phenotyping work which has led to a new precision medicine therapeutic framework to understand and treat OSA and for my research on the role of arousal mechanisms and hypnotics in OSA pathogenesis and treatment. This work has had a major impact in advancement of OSA pathophysiology and realignment of the therapeutic agenda for this common, chronic health condition.