• 4887 Citations
  • 30 h-Index
20022020

Research output per year

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Personal profile

Research Biography

Since 2014, David is an European Molecular Biology Laboratory (EMBL) Australia Group Leader in the Infection and Immunity Theme at the South Australian Health and Medical Research Institute (SAHMRI). He also holds a joint faculty appointment as Associate Professor at the College of Medicine & Public Health, Flinders University. David heads a multi-disciplinary group that is equally divided between bioinformatics and experimental systems biology. On the wet-lab side, his group employs in vitro and in vivo experimental and clincial models coupled with systems biology approaches to investigate the interplay between the microbiome, vaccines and the immune system. On the bioinformatics side, his group leads the development of InnateDB.com, an internationally recognised systems biology platform for innate immunity networks and he also leads the computational biology aspects of ‚¬12 million European Commission funded project called PRIMES, which is investigating how to model and subsequently therapeutically target protein interaction networks in cancer.

His Group is currently supported by; EMBL Australia; The NHMRC; Cancer Australia and The Garnett Passe and Rodney Williams Memorial Foundation. He has published ~70 papers in journals including Cell Host & Microbe, Cell Systems, Bioinformatics, Molecular Systems Biology, and Science and his publications have received more than 5000 citations. He has given invited talks on 6 continents.

Research Interests

David heads a multi-disciplinary group that is equally divided between bioinformatics and experimental systems biology. On the wet-lab side, his group employs in vitro and in vivo experimental and clincial models coupled with systems biology approaches to investigate the interplay between the microbiome, vaccines and the immune system. On the bioinformatics side, his group leads the development of InnateDB.com, an internationally recognised systems biology platform for innate immunity networks and he also leads the computational biology aspects of ‚¬12 million European Commission funded project called PRIMES, which is investigating how to model and subsequently therapeutically target protein interaction networks in cancer.

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Research Output

  • 4887 Citations
  • 30 h-Index
  • 71 Article
  • 1 Chapter
  • 1 Comment/debate

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Kennedy, S. A., Jarboui, M. A., Srihari, S., Raso, C., Bryan, K., Dernayka, L., Charitou, T., Bernal-Llinares, M., Herrera-Montavez, C., Krstic, A., Matallanas, D., Kotlyar, M., Jurisica, I., Curak, J., Wong, V., Stagljar, I., LeBihan, T., Imrie, L., Pillai, P., Lynn, M. A. & 21 others, Fasterius, E., Al-Khalili Szigyarto, C., Breen, J., Kiel, C., Serrano, L., Rauch, N., Rukhlenko, O., Kholodenko, B. N., Iglesias-Martinez, L. F., Ryan, C. J., Pilkington, R., Cammareri, P., Sansom, O., Shave, S., Auer, M., Horn, N., Klose, F., Ueffing, M., Boldt, K., Lynn, D. J. & Kolch, W., 24 Jan 2020, In : Nature Communications. 11, 14 p., 499.

Research output: Contribution to journalArticle

Open Access
File
  • 3 Citations (Scopus)

    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

    Nassar, Z. D., Mah, C. Y., Dehairs, J., Burvenich, I. J., Irani, S., Centenera, M. M., Helm, M., Shrestha, R. K., Moldovan, M., Don, A. S., Holst, J., Scott, A. M., Horvath, L. G., Lynn, D. J., Selth, L. A., Hoy, A. J., Swinnen, J. V. & Butler, L. M., 20 Jul 2020, In : eLife. 9, 34 p., e54166.

    Research output: Contribution to journalArticle

    Open Access
    File
  • National Trends in Antibiotic Use in Australian Residential Aged Care Facilities, 2005-2016

    Sluggett, J., Moldovan, M., Lynn, D., Papanicolas, L., Crotty, M., Whitehead, C., Wesselingh, S., Rogers, G. & Inacio, M. C., 27 May 2020, In : Clinical Infectious Diseases. 8 p.

    Research output: Contribution to journalArticle

  • Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set

    Del-Toro, N., Duesbury, M. J., Koch, M., Perfetto, L., Shrivastava, A. R., Ochoa, D., Wagih, O., Piñero, J., Kotlyar, M., Pastrello, C., Beltrão, P., Furlong, L. I., Jurisica, I., Hermjakob, H., Orchard, S. E., Porras, P., Khadake, J., Meldal, B. H. M., Panni, S., Thorneycroft, D. & 22 others, Van Roey, K., Abbani, S., Salwínski, L., Pellegrini, M., Iannuccelli, M., Licata, L., Cesareni, G., Roechert, B., Bridge, A. J., Ammari, M. G., McCarthy, F. M., Broackes-Carter, F. C., Campbell, N. H., Melidoni, A. N., Rodriguez-Lopez, M., Lovering, R. C., Jagannathan, S., Chen, C., Lynn, D. J., Ricard-Blum, S., Mahadevan, U. & Raghunath, A., 2019, In : Nature Communications. 10, 1, 10.

    Research output: Contribution to journalArticle

  • 9 Citations (Scopus)

    Changes in the composition of the gut microbiota and the blood transcriptome in preterm infants at less than 29 weeks gestation diagnosed with bronchopulmonary dysplasia

    Ryan, F. J., Drew, D. P., Douglas, C., Leong, L. E. X., Moldovan, M., Lynn, M., Fink, N., Sribnaia, A., Penttila, I., McPhee, A. J., Collins, C. T., Makrides, M., Gibson, R. A., Rogers, G. B. & Lynn, D. J., 29 Oct 2019, In : mSystems. 4, 5, 17 p., e00484.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    11 Downloads (Pure)