• Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
19992021

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Personal profile

Research Interests

My research over the last 15 years has been focusing on the transcriptional and microRNA regulation of UDP-glucuronosyltransferases (UGTs) in response to chemotherapeutic drugs and sex steroid hormones. My research discovered a series of transcriptional factors and microRNAs that control the expression and activity of UGT enzymes in drug-metabolically relevant organs (Liver) and/or sex hormone-sensitive cancers (Prostate and Breast cancer). These studies have been published in over 20 articles in prestigious international journals in the fields of Pharmacology and Cancers, including Molecular pharmacology, Journal of Pharmacology and Experimental Therapeutics, Drug Metabolism and Disposition, Drug Metabolism Reviews, Pharmacology & and Therapeutics, and Cancer Research”.

My research recently extends to cover ADME genes, a group of approximately 300 genes that are involved in drug Absorption, Distribution, Metabolism, Excretion (ADME). ADME genes are also involved in clearing endogenous compounds (steroids, fatty acids, bile acids, lipids). My bioinformatic analysis of The Cancer Genome Atlas (TCGA) datasets show deregulation of ADME genes in cancers and their association with cancer patient survival. These discoveries have been recently published.

Over these years, my research also discovered novel androgen receptor splice variants (ARVs) and showed for the first time ARV expression in breast cancer.  These discoveries are clinically relevant given their potential role in mediating anti-androgen resistance in breast cancers treated with anti-antiandrogens.

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