• 657 Citations
  • 16 h-Index
19992019

Research output per year

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Personal profile

Research Interests

Utimately, the therapeutic efficacy of drugs is coordinately regulated by ADME genes, a group of approximately 300 genes that are involved in drug Absorption, Distribution, Metabolism, Excretion. ADME genes are also involved in detoxification and clearance of endogenous (steroids, fatty acids, bile acids, lipids) and exogenous (carcinogens) cancer-modulating compounds. The expression and activity of ADME genes define the capacity of the body and tissue to metabolize and clear drugs and cancer-modulating molecules.  Hence, the deregulation of ADME genes may relate to drug resistance and cancer development and progression. My research covers the whole set of ADME genes with primary interest on UDP-glucuronosyltransferases (UGTs). 

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Research Output

  • 12 Citations (Scopus)

    The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms

    Meech, R., Hu, D. G., McKinnon, R., Mubaroka, S., Haines, A., Nair, P., Rowland, A. & Mackenzie, P., Apr 2019, In : PHYSIOLOGICAL REVIEWS. 99, 2, p. 1153-1222 70 p.

    Research output: Contribution to journalArticle

  • 13 Citations (Scopus)
  • 2 Citations (Scopus)
  • 4 Citations (Scopus)
  • 3 Citations (Scopus)