Dr Dusan Matusica

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20062021

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Personal profile

Research Biography

Dr. Dusan Matusica was appointed as a Lecturer in Anatomy & Histology and Research Associate in the Pain & Pulmonary Neurobiology Lab within the Flinders Medical Science & Technology cluster of the School of Medicine in 2014. He completed his undergraduate studies at Flinders University majoring in Neuroscience and Biochemistry, going on to complete his Honours degree at the Flinders University School of Medicine in Neurophysiology, and received his PhD in Neurobiology in 2008. In 2010 he joined the Queensland Brain Institute at the Univerity of Queensland as a Postdoctoral Fellow in the Alzheimer's disease research group. His research at QBI focused on identifying the regulators of nerve cell death, with the primary interest of understanding the celular and molecular mechanisms causing neurodegenerative diseases including Alzheimer's disease (AD) and Amyotropic Lateral Sclerosis (ALS).

His primary research interest lie in understanding the cellular and molecular mechanisms of neuronal injury resulting in pain and/or neurodegeneration. His research focuses on a family of growth factors called neurotrophins (NTs). NTs belong to a family of structurally and functionally related proteins responsible for diverse actions in the developing peripheral and central nervous systems. They are important regulators of neuronal function, affecting neuronal survival and growth. They are able to regulate cell death and survival in development as well as in pathophysiologic states.

The overarching focus of his research are molecular and cellular mechanisms regulating the neuronal trafficking, and signalling pathways involved in the function and development of central and peripheral neurons, as well as the dysregulation of these mechanisms in the pathophysiology of neurodegenerative conditions and chronic pain.

Research Interests

Development of high-throughput cell line models for the study of pain signalling.

Neurobiology of growth factors and their receptors in motor neurone disease (MND).

Functional and structural interactions between neurotrophin receptors Trk, p75NTR and sortilin.

Development of Bio-Nano-Chip microfluidic devices for point of care (POC) testing.

Epigenetic mechanisms regulating pain.

External positions

Postdoctoral Fellow, University of Queensland

16 Feb 20101 Mar 2014

Research Officer, Biosensis Pty Ltd

20032010

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