• 494 Citations
  • 11 h-Index
19952020

Research output per year

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Personal profile

Research Interests

Oncofertility

  • Anti-cancer radiotherapy and chemotherapy can cause early menopause and infertility. This research area is about developing approaches to preserving the fertility of female cancer survivors.

Medical Biotechnology and Reproductive Toxicology

  • The early lab-based development of therapies with the potential to prevent breast, uterine and ovarian cancer.
  • The use of human reproductive cells in vitro (including primary-derived human granulosa cells and spermatozoa, embryonic stem cells, and human breast, uterine and ovarian cancer cell lines), as well as in vitro mouse cultures, to assess the toxicity, or the activity, of novel bioactive extracts, nanoparticles, agrichemicals (eg pesticides and herbicides), new pharmaceutical agents or bioremediation products.
  • Development and application of 3D cell culture methods, and their application to developing novel contraceptives.

Environmental Biotechnology

  • The development and application of assays to detect and quantify endocrine disrupting compounds (EDCs) in surface and drinking waters, recycled water and wastewater, using SPE-ELISA, HPLC, E-screen, and human cell lines in novel in vitro assays.
  • The characterisation of particles in wastewater, and their effects on recycling

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Research Output

Gamma tocopherol reduced chemotherapeutic-induced ROS in an ovarian granulosa cell line, but not in breast cancer cell lines in vitro

Gonzalez, D. F. & Young, F., 7 Jan 2020, In : Antioxidants. 9, 1, 19 p., 51.

Research output: Contribution to journalArticle

Open Access
File
  • 2 Citations (Scopus)

    Effect of Chemotherapeutics and Tocopherols on MCF-7 Breast Adenocarcinoma and KGN Ovarian Carcinoma Cell Lines In Vitro

    Figueroa, D., Asaduzzaman, M. & Young, F., 15 Jan 2019, In : BioMed research international. 2019, 13 p., 6146972.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    1 Downloads (Pure)

    Ovarian Follicle Disaggregation to Assess Granulosa Cell Viability

    Asaduzzaman, M., Figueroa Gonzalez, D. & Young, F., May 2018, In : International Journal of Clinical Medicine. 9, 5, p. 377-399 23 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Open Access
    File
  • 11 Citations (Scopus)
    7 Downloads (Pure)

    Three Dimensional In Vitro Culture of Murine Secondary Follicles in a Defined Synthetic Matrix

    Asaduzzaman, M., Cui, X., Zhang, H. & Young, F., Jul 2018, In : Journal of Biomaterials and Nanobiotechnology. 9, 3, p. 244-262 19 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Activities

    • 1 Invited talk

    Reproductive and toxicity preclinical testing

    Fiona Young (Speaker)

    5 Nov 20129 Nov 2012

    Activity: Talk or presentation typesInvited talk