• 1396 Citations
  • 19 h-Index
19952020

Research output per year

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Personal profile

Research Biography

I have an interest in understanding  two major signalling networks that are implicated in tumourigensis and diabetes in humans. I am a biochemist (obtained a BSc in Biochemistry 1989-1992), a Geneticits  (obtained a  MSc in Molecular Genetics 1992-1994) and a Cell Biologist (obtained a PhD in cell biology (1995-1998 ) all from the University of Copenhagen, Denmark. In 1998, I joined the laboratory of Professor Iain Hagan at The University of Manchester/Paterson Institute for Cancer Research as a postdoctoral Research Fellow to study the role of protein kinases in regulating cell cycle progression in fission yeast. I then worked as a Research Associate with Nobel laureate Sir Paul Nurse at the Rockefeller University in New York, USA, studying the role of protein kinases in regulating cell cycle progression in fission yeast. In 2005, I became a Lecturer within the Faculty of Life Sciences at The University of Manchester, UK. In December 2009, I was awarded a Cancer Research UK Senior Research Fellowship. My appointment to Flinders University as an Associate Professor along with a Faculty appointment at SAHMRI (South Australian Health and Medical Research Institute) as part of the Nutrition and Metabolism theme commenced 2015. At Flinders University my group is a member of the Flinders Centre for Innovation in Cancer.

Research Interests

Environmental control of cell growth and cell division laboratory.

Target Of Rapamycin TOR and AMPK signalling networks are the major nutrient sensing pathways in all eukaryotic cells. Our work aims to extend our understanding of these major signalling networks that are implicated in tumourigensis and diabetes in humans to adjust growth and cellular metabolism in response to changes in the nutrient environment. Our main model organisms are the fission yeast S. pombe and mammalian tissue culture models. We use fission yeast as an ideal model system in which to establish the core principles of AMPK and TOR signalling before transposing rigorously tested predictions to human cells.

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Research Output

  • 1396 Citations
  • 19 h-Index
  • 32 Article
  • 2 Chapter
  • 1 Letter

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

Ling, N. X. Y., Kaczmarek, A., Hoque, A., Davie, E., Ngoei, K. R. W., Morrison, K. R., Smiles, W. J., Forte, G. M., Wang, T., Lie, S., Dite, T. A., Langendorf, C. G., Scott, J. W., Oakhill, J. S. & Petersen, J., 20 Jan 2020, In : Nature Metabolism. 2, 1, p. 41-49 9 p.

Research output: Contribution to journalLetter

  • 7 Citations (Scopus)

    Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling

    Forte, G. M., Davie, E., Lie, S., Franz-Wachtel, M., Ovens, A. J., Wang, T., Oakhill, J. S., Macek, B., Hagan, I. M. & Petersen, J., 2019, In : Journal of Cell Science. 132, 7, 12 p., jcs223925.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 4 Citations (Scopus)
    20 Downloads (Pure)

    Micromanaging aerobic respiration and glycolysis in cancer cells

    Valinezhad Orang, A., Petersen, J., McKinnon, R. & Michael, M., May 2019, In : Molecular Metabolism. 23, p. 98-126 29 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 21 Citations (Scopus)
    4 Downloads (Pure)

    The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1

    Lie, S., Wang, T., Forbes, B., Proud, C. & Petersen, J., 1 Dec 2019, Scientific Reports , 9, 1, p. 1461.

    Research output: Contribution to specialist publicationArticle

  • 3 Citations (Scopus)

    The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of rapamycin activity

    Lie, S., Banks, P., Lawless, C., Lydall, D. & Petersen, J., 2018, In : Open Biology. 8, 5, 18 p., 180015.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)