Research output per year
Research output per year
Personal profile
Research Biography
Jianling is a biochemist who has studied the cellular signalling pathways that involve mTOR, a master regulator of cell anabolism. He has built up a continuous track record based on mTOR-related publications, and has authored 40 peer-reviewed publications, including 18 first/last author papers in top-ranking journals; e.g. Curr Biol, Cell Mol Life Sci, Diabetologia, Int J Cancer, J Biol Chem, Mol Cell Biol, J Mol Biol, among others. His articles has thus far been cited 1321 times (search date: 07/08/2020, Google Scholar). Most of these papers are related to protein synthesis/mRNA translation, tumour growth/survival/metastasis and pancreatic β-cell functions. He also hold two patents and authored two book chapters and has given 8 presentations at international conferences. He recently joint A/Prof. Luke Selth's lab at Flinders Centre for Innovation in Cancer and his research interests have now evolved towards studying the regulation of mRNA translation in prostate cancer progression.
Education/Academic qualification
University of Leicester, Leicester
Award Date: 13 Jul 2012
Keywords
- RM Therapeutics. Pharmacology
- biochemistry
- physiology
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Bicuculline regulated protein synthesis is dependent on Homer1 and promotes its interaction with eEF2K through mTORC1-dependent phosphorylation
Gladulich, L. F. H., Xie, J., Jensen, K. B., Kamei, M., Paes-de-Carvalho, R., Cossenza, M. & Proud, C. G., May 2021, In: Journal of Neurochemistry. 157, 4, p. 1086-1101 16 p.Research output: Contribution to journal › Article › peer-review
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Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells
De Poi, S. P., Xie, J., Smales, C. M. & Proud, C. G., Jul 2021, In: Biotechnology and Bioengineering. 118, 7, p. 2422-2434 13 p.Research output: Contribution to journal › Article › peer-review
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Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis
Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., Lenchine, R. V., De Poi, S., Jensen, K. B., Trim, P. J., Snel, M. F., Kamei, M., Martin, S. K., Fitter, S., Tian, S., Wang, X. & 3 others, , Jan 2021, In: Cellular and Molecular Life Sciences. 78, 1, p. 249-270 22 p.Research output: Contribution to journal › Article › peer-review
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Regulation of mrna translation by hormone receptors in breast and prostate cancer
Xie, J., Kusnadi, E. P., Furic, L. & Selth, L. A., 1 Jul 2021, In: Cancers. 13, 13, 26 p., 3254.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling
Xie, J., De Poi, S. P., Humphrey, S. J., Hein, L. K., Bruning, J. B., Pan, W., Selth, L. A., Sargeant, T. J. & Proud, C. G., Apr 2021, In: Cellular and Molecular Life Sciences. 78, 8, p. 4035-4052 18 p.Research output: Contribution to journal › Article › peer-review