Research output per year
Research output per year
Personal profile
Research Biography
From the beginning of my PhD, my research interests have been focused on delineating the cellular signalling pathways that regulate protein synthesis, in particular mTOR (mechanistic target of rapamycin), a master protein that controls cell growth, which is of key importance in human diseases such as cancer. My very recent discovery concerns the oversupply of nutrients, in particular amino acids, results in the build-up of faulty proteins within cells and shortens lifespan. This study highlights the detrimental effects of over-nutrition and the importance of a healthier, low-protein diet, and has attracted attention from several media outlets in both Australia and in Brazil, where part of the study was undertaken.
I have so far authored 53 peer-reviewed publications, including 24 first/last author papers in top-ranking journals such as Nature Cell Biology, Current Biology, Diabetologia, Cellular & Molecular Life Sciences, International Journal of Cancer, among others. My articles have thus far been cited 1983 times (11/04/2022, Google Scholar, h-index: 24). I hold four patents, authored four book chapters and have given eight presentations at international conferences.
Stemming from those studies, my recent research interests have evolved towards studying the role of protein synthesis, transcription and epigenomics in prostate cancer progression. I have recently been awarded a seed funding by the SA state’s prestigious South Australian Health and Medical Research Institute (SAHMRI) and the Hospital Research Foundation (THRF) to advance the research in this topic.
Education/Academic qualification
PhD, University of Leicester, Leicester
Award Date: 13 Jul 2012
Keywords
- RM Therapeutics. Pharmacology
- biochemistry
- physiology
Fingerprint
Dive into the research topics where Jianling Xie is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth
Gillis, J. L., Hinneh, J. A., Ryan, N. K., Irani, S., Moldovan, M., Quek, L-E., Shrestha, R. K., Hanson, A. R., Xie, J., Hoy, A. J., Holst, J., Centenera, M. M., Mills, I. G., Lynn, D. J., Selth, L. A. & Butler, L. M., Aug 2021, In: eLife. 10, 27 p., e62592.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)9 Downloads (Pure) -
Bicuculline regulated protein synthesis is dependent on Homer1 and promotes its interaction with eEF2K through mTORC1-dependent phosphorylation
Gladulich, L. F. H., Xie, J., Jensen, K. B., Kamei, M., Paes-de-Carvalho, R., Cossenza, M. & Proud, C. G., May 2021, In: Journal of Neurochemistry. 157, 4, p. 1086-1101 16 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells
De Poi, S. P., Xie, J., Smales, C. M. & Proud, C. G., Jul 2021, In: Biotechnology and Bioengineering. 118, 7, p. 2422-2434 13 p.Research output: Contribution to journal › Article › peer-review
-
Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis
Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., Lenchine, R. V., De Poi, S., Jensen, K. B., Trim, P. J., Snel, M. F., Kamei, M., Martin, S. K., Fitter, S., Tian, S., Wang, X. & 3 others, , Jan 2021, In: Cellular and Molecular Life Sciences. 78, 1, p. 249-270 22 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Regulation: mTOR and its substrates
Proud, C. G. & Xie, J., 29 Jul 2021, Encyclopedia of Biological Chemistry. Jez, J. (ed.). 3rd ed. Netherlands: Elsevier, Vol. 1. p. 614-630 17 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review