Personal profile
Research Biography
From the beginning of my PhD, my research interests have been focused on delineating the cellular signalling pathways that regulate protein synthesis, in particular mTOR (mechanistic target of rapamycin), a master protein that controls cell growth, which is of key importance in human diseases such as cancer. My very recent discovery concerns the oversupply of nutrients, in particular amino acids, results in the build-up of faulty proteins within cells and shortens lifespan. This study highlights the detrimental effects of over-nutrition and the importance of a healthier, low-protein diet, and has attracted attention from several media outlets in both Australia and in Brazil, where part of the study was undertaken.
I have so far authored 53 peer-reviewed publications, including 24 first/last author papers in top-ranking journals such as Nature Cell Biology, Current Biology, Diabetologia, Cellular & Molecular Life Sciences, International Journal of Cancer, among others. My articles have thus far been cited 1983 times (11/04/2022, Google Scholar, h-index: 24). I hold four patents, authored four book chapters and have given eight presentations at international conferences.
Stemming from those studies, my recent research interests have evolved towards studying the role of protein synthesis, transcription and epigenomics in prostate cancer progression. I have recently been awarded a seed funding by the SA state’s prestigious South Australian Health and Medical Research Institute (SAHMRI) and the Hospital Research Foundation (THRF) to advance the research in this topic.
Education/Academic qualification
PhD, PhD Cell Physiology and Pharmacology, University of Leicester, Leicester
Award Date: 13 Jul 2012
Keywords
- RM Therapeutics. Pharmacology
- biochemistry
- physiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
-
SDG 14 Life Below Water
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Cellular Signaling of Amino Acid Metabolism in Prostate Cancer
Yao, P., Cao, S., Zhu, Z., Wen, Y., Guo, Y., Liang, W. & Xie, J., 17 Jan 2025, In: International Journal of Molecular Sciences. 26, 2, 19 p., 776.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)37 Downloads (Pure) -
Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival
Xie, J., Shen, K., Liang, W., Kuang, Z., Shrestha, R. K., Hanson, A. R., Townley, S. L., He, M., Yu, S., Zhou, P., Zhu, L., Gong, Z., Ao, X., Rao, S. R., Zhang, Q., Chen, K., Wei, J., Marri, S., Snel, M. F. & Irani, S. & 10 others, , 21 Oct 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 42, 12 p., e2509222122.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)8 Downloads (Pure) -
CDK9 inhibition inhibits multiple oncogenic transcriptional and epigenetic pathways in prostate cancer
Rahman, R., Rahaman, M. H., Hanson, A. R., Choo, N., Xie, J., Townley, S. L., Shrestha, R., Hassankhani, R., Islam, S., Ramm, S., Simpson, K. J., Risbridger, G. P., Best, G., Centenera, M. M., Balk, S. P., Kichenadasse, G., Taylor, R. A., Butler, L. M., Tilley, W. D. & Conn, S. J. & 3 others, , 5 Oct 2024, In: British Journal of Cancer. 131, 6, p. 1092-1105 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)93 Downloads (Pure) -
Correction to: CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer
Rahman, R., Rahaman, M. H., Hanson, A. R., Choo, N., Xie, J., Townley, S. L., Shrestha, R., Hassankhani, R., Islam, S., Ramm, S., Simpson, K. J., Risbridger, G. P., Best, G., Centenera, M. M., Balk, S. P., Kichenadasse, G., Taylor, R. A., Butler, L. M., Tilley, W. D. & Conn, S. J. & 3 others, , 30 Nov 2024, In: British Journal of Cancer. 131, 10, p. 1719 1 p.Research output: Contribution to journal › Comment/debate
Open AccessFile40 Downloads (Pure) -
Correction to “Using Imidazo[2,1-b][1,3,4]thiadiazol Skeleton to Design and Synthesize Novel MNK Inhibitors” (ACS Med. Chem. Lett. (2023)14:1 (83−91) DOI: 10.1021/acsmedchemlett.2c00442)
Jin, X., Qiu, T., Xie, J., Wei, X., Wang, X., Yu, R., Proud, C. & Jiang, T., 9 Mar 2023, In: ACS Medicinal Chemistry Letters. 14, 3, p. 344 1 p.Research output: Contribution to journal › Comment/debate
1 Citation (Scopus)