Dr Joel Castro Kraftchenko

  • 1739 Citations
  • 24 h-Index

Research output per year

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Personal profile

Research Biography

Dr. Joel Castro Kraftchenko (known as DR Joel Castro on his publications) is based at the South Australian Health and Medical Research Institute (SAHMRI).

He received his PhD in 2008 at Flinders University.

His research involves pre-clinical and translational science. Translational evidence of Dr. Castro's research, includes his first author publication in Gastroenterology (best journal in his discipline), describing the mechanisms of action by which Linaclotide, an FDA approved drug, relieves chronic visceral pain in IBS patients.

Dr Castro's technical strengths include an array of techniques ranging from the cellular level to in vivo animal experiments. He is an expert on recordings from visceral nerves and pain quantification assays in vivo. He has published more than 40 articles, reviews and chapters  including high-impact publications in journal such as Nature, Cell, Nature Communications, Gastroenterology, Gut, Pain, Scientific Reports and JCI insights.

Research Interests




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Research Output

  • 1739 Citations
  • 24 h-Index
  • 41 Article
  • 8 Paper
  • 2 Chapter
  • 2 Review article
  • 2 Citations (Scopus)

    Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

    Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., Schober, G., O'Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. W. & Brierley, S. M., 17 Oct 2019, In : JCI insight. 4, 20, e131712.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)
  • Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk

    Ge, P., Ren, J., Harrington, A. M., Grundy, L., Castro, J., Brierley, S. M. & Hannig, G., 1 Nov 2019, In : Pain. 160, 11, p. 2566-2579 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 13 Downloads (Pure)

    NaV1.6 regulates excitability of mechanosensitive sensory neurons

    Israel, M. R., Tanaka, B. S., Castro, J., Thongyoo, P., Robinson, S. D., Zhao, P., Deuis, J. R., Craik, D. J., Durek, T., Brierley, S. M., Waxman, S. G., Dib-Hajj, S. D. & Vetter, I., 15 Jul 2019, In : Journal of Physiology. 597, 14, p. 3751-3768 18 p.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)