Research output per year
Research output per year
Personal profile
Research Biography
Dr. Joel Castro Kraftchenko (known as DR Joel Castro on his publications) is based at the South Australian Health and Medical Research Institute (SAHMRI).
He received his PhD in 2008 at Flinders University.
His research involves pre-clinical and translational science. Translational evidence of Dr. Castro's research, includes his first author publication in Gastroenterology (best journal in his discipline), describing the mechanisms of action by which Linaclotide, an FDA approved drug, relieves chronic visceral pain in IBS patients.
Dr Castro's technical strengths include an array of techniques ranging from the cellular level to in vivo animal experiments. He is an expert on recordings from visceral nerves and pain quantification assays in vivo. He has published more than 40 articles, reviews and chapters including high-impact publications in journal such as Nature, Cell, Nature Communications, Gastroenterology, Gut, Pain, Scientific Reports and JCI insights.
Research Interests
Neurosciences
Pharmacology
Physiology
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Research output
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A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities
Castro, J., Maddern, J., Grundy, L., Manavis, J., Harrington, A. M., Schober, G. & Brierley, S. M., Apr 2021, In: FASEB Journal. 35, 4, 20 p., e21430.Research output: Contribution to journal › Article › peer-review
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A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome
Cardoso, F. C., Castro, J., Grundy, L., Schober, G., Garcia-Caraballo, S., Zhao, T., Herzig, V., King, G. F., Brierley, S. M. & Lewis, R. J., Feb 2021, In: Pain. 162, 2, p. 569-581 13 p.Research output: Contribution to journal › Article › peer-review
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Pharmacological modulation of voltage-gated sodium (NaV) channels alters nociception arising from the female reproductive tract
Castro, J., Maddern, J., Erickson, A., Caldwell, A., Grundy, L., Harrington, A. M. & Brierley, S. M., 1 Jan 2021, In: Pain. 162, 1, p. 227-242 16 p.Research output: Contribution to journal › Article › peer-review
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Chronic intra-colonic linaclotide administration alters glial activation in a mouse model of chronic visceral hypersensitivity
Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G. & Brierley, S., May 2020, In: Gastroenterology. 158, 6, Supplement 1, p. S-803 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1 receptor and TRPV1
Grundy, L., Caldwell, A., Garcia Caraballo, S., Erickson, A., Schober, G., Castro, J., Harrington, A. M. & Brierley, S. M., Feb 2020, In: American journal of physiology. Renal physiology. 312, 2, p. F298-F314 17 p.Research output: Contribution to journal › Article › peer-review
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