Research Output per year
Personal profile
Research Biography
Dr. Joel Castro Kraftchenko (known as DR Joel Castro on his publications) is based at the South Australian Health and Medical Research Institute (SAHMRI).
He received his PhD in 2008 at Flinders University.
His research involves pre-clinical and translational science. Translational evidence of Dr. Castro's research, includes his first author publication in Gastroenterology (best journal in his discipline), describing the mechanisms of action by which Linaclotide, an FDA approved drug, relieves chronic visceral pain in IBS patients.
Dr Castro's technical strengths include an array of techniques ranging from the cellular level to in vivo animal experiments. He is an expert on recordings from visceral nerves and pain quantification assays in vivo. He has published more than 40 articles, reviews and chapters including high-impact publications in journal such as Nature, Cell, Nature Communications, Gastroenterology, Gut, Pain, Scientific Reports and JCI insights.
Research Interests
Neurosciences
Pharmacology
Physiology
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Research Output
Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1 receptor and TRPV1
Grundy, L., Caldwell, A., Garcia Caraballo, S., Erickson, A., Schober, G., Castro, J., Harrington, A. M. & Brierley, S. M., Feb 2020, In : American journal of physiology. Renal physiology. 312, 2, p. F298-F314 17 p.Research output: Contribution to journal › Article
Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity
Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., Schober, G., O'Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. W. & Brierley, S. M., 17 Oct 2019, In : JCI insight. 4, 20, e131712.Research output: Contribution to journal › Article
Open Access
File
Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord
Harrington, A. M., Caraballo, S. G., Maddern, J. E., Grundy, L., Castro, J. & Brierley, S. M., 1 Sep 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 317, 3, p. G285-G303 19 p.Research output: Contribution to journal › Article
Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk
Ge, P., Ren, J., Harrington, A. M., Grundy, L., Castro, J., Brierley, S. M. & Hannig, G., 1 Nov 2019, In : Pain. 160, 11, p. 2566-2579 14 p.Research output: Contribution to journal › Article
Open Access
File
NaV1.6 regulates excitability of mechanosensitive sensory neurons
Israel, M. R., Tanaka, B. S., Castro, J., Thongyoo, P., Robinson, S. D., Zhao, P., Deuis, J. R., Craik, D. J., Durek, T., Brierley, S. M., Waxman, S. G., Dib-Hajj, S. D. & Vetter, I., 15 Jul 2019, In : Journal of Physiology. 597, 14, p. 3751-3768 18 p.Research output: Contribution to journal › Article