Research output per year
Research output per year
Personal profile
Research Biography
Dr. Joel Castro Kraftchenko (known as DR Joel Castro on his publications) is based at the South Australian Health and Medical Research Institute (SAHMRI).
He received his PhD in 2008 at Flinders University.
His research involves pre-clinical and translational science. Translational evidence of Dr. Castro's research, includes his first author publication in Gastroenterology (best journal in his discipline), describing the mechanisms of action by which Linaclotide, an FDA approved drug, relieves chronic visceral pain in IBS patients.
Dr Castro's technical strengths include an array of techniques ranging from the cellular level to in vivo animal experiments. He is an expert on recordings from visceral nerves and pain quantification assays in vivo. He has published more than 40 articles, reviews and chapters including high-impact publications in journal such as Nature, Cell, Nature Communications, Gastroenterology, Gut, Pain, Scientific Reports and JCI insights.
Research Interests
Neurosciences
Pharmacology
Physiology
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Research output
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Clodronate Treatment Prevents Vaginal Hypersensitivity in a Mouse Model of Vestibulodynia
Castro, J., Harrington, A. M., Chegini, F., Matusica, D., Spencer, N. J., Brierley, S. M., Haberberger, R. V. & Barry, C. M., 18 Jan 2022, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 784972.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain
Brierley, S. M., Grundy, L., Castro, J., Harrington, A. M., Hannig, G. & Camilleri, M., 1 Feb 2022, In: Trends in Pharmacological Sciences. 43, 2, p. 110-122 13 p.Research output: Contribution to journal › Review article › peer-review
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Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents
Castro, J., Garcia-Caraballo, S. C., Maddern, J., Schober, G., Lumsden, A., Harrington, A., Schmiel, S., Lindstrom, B., Adams, J. & Brierley, S., 1 Jan 2022, In: Pain. 163, 1, p. E72-E86 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)23 Downloads (Pure) -
Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension
Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N. J., Dong, X., Castro, J., Harrington, A. M. & Brierley, S. M., 28 Apr 2021, In: Journal of Neuroscience. 41, 17, p. 3900-3916 17 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities
Castro, J., Maddern, J., Grundy, L., Manavis, J., Harrington, A. M., Schober, G. & Brierley, S. M., Apr 2021, In: FASEB Journal. 35, 4, 20 p., e21430.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)