Professor Miners was a Postdoctoral Research Scientist at Oxford University before taking up a position as Toxicologist in the Department of Biochemistry and Chemical Pathology of Flinders Medical Centre in 1977. He joined the Department of Clinical Pharmacology in 1978. Until 2002 Prof Miners held the positions of Chief Pharmacologist and Professor in Clinical Pharmacology. From 2003 to 2013, he was Professor and Head of the Department of Clinical Pharmacology. He currently holds a part-time research only position as Professor of Pharmacology and Therapeutics.
Drug and chemical metabolism in humans, particularly sources of variability in drug elimination and its pharmacokinetic and therapeutic consequences. Current interests include:
- Structure-function relationships and genetic polymorphisms of human UDP-glucuronosyltransferases and cytochromes P450
- In vitro (in vitro-in vivo extrapolation) and computational models for the prediction of drug and chemical metabolism parameters in vivo
- Drug-drug interactions
- Metabolomics (including biomarkers of drug response)
- Therapeutic drug monitoring