• 9556 Citations
  • 33 h-Index
1989 …2020

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Personal profile

Research Biography

Professor Jonathan Gleadle is Professor of Medicine at Flinders University (since February 2017) and Consultant Nephrologist at Flinders Medical Centre. He undertook a DPhil at Oxford from 1993-1997 supervised by Professor Peter Ratcliffe entitled “The mechanism of oxygen sensing by mammalian cells”. He was then Clinical Lecturer in Nephrology and General Medicine at the University of Oxford (1997-2001) and University Lecturer in Nephrology and General Medicine, University of Oxford (2001-2007). Work during this time contributed to the award of the 2019 Nobel Prize in Medicine to Peter Ratcliffe with contributions to 23 co-authored publications (including 5 as first author and 3 as senior author) notably including characterising and naming the mammalian prolyl hydroxylase enzymes (PHD 1-3) which sense oxygen and control transcriptional regulation via Hypoxia inducible factors. He has generated over 90 highly cited publications in the fields of oxygen sensing, microRNAs and clinical nephrology. 

Research Interests

Current research focusses on the mechanism underlying compensatory renal hypertrophy, the translation and clinical relevance of urine diagnostics in cancer and the molecular and cellular responses to oxygen. Recent clinical studies have examined the use of novel surfaces to facilitate urine bladder and prostate cancer diagnostics, renal complications following cardiac surgery and cardiac MR imaging in patients with renal disease.  

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Research Output

Plasma enabled devices for the selective capture and photodynamic identification of prostate cancer cells

Shirazi, H. S., Chan, K. M., Rouget, J., Ostrikov, K., McNicholas, K., Li, J., Butler, L., Gleadle, J. M., Vasilev, K. & MacGregor, M., 15 May 2020, In : Biointerphases. 15, 3, 1 p., 031002.

Research output: Contribution to journalArticle

Open Access
  • 2 Citations (Scopus)

    Probing hexaminolevulinate mediated ppix fluorescence in cancer cell suspensions in the presence of chemical adjuvants

    Chan, K. M., Gleadle, J., Vasilev, K. & Macgregor, M., 22 Apr 2020, In : International Journal of Molecular Sciences. 21, 8, 16 p., 2963.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)

    Shedding Light on Bladder Cancer Diagnosis in Urine

    Chan, K. M., Gleadle, J., Li, J., Vasilev, K. & MacGregor, M., 8 Jun 2020, In : Diagnostics. 10, 6, 20 p., 383.

    Research output: Contribution to journalReview article

    Open Access
    File
  • 1 Citation (Scopus)

    Biosensor device for the photo-specific detection of immuno-captured bladder cancer cells using hexaminolevulinate: An ex-vivo study

    Chan, K. M., Vasilev, K., Shirazi, H. S., McNicholas, K., Li, J., Gleadle, J. & MacGregor, M., Dec 2019, In : Photodiagnosis and Photodynamic Therapy. 28, p. 238-247 10 p.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)

    Compensatory renal hypertrophy following nephrectomy: When and how?

    Rojas-Canales, D., Li, J., Makuei, L. & Gleadle, J., 1 Dec 2019, In : Nephrology. 24, 12, p. 1225-1232 8 p., 13578.

    Research output: Contribution to journalArticle

  • 5 Citations (Scopus)