Research output per year
Research output per year
Personal profile
Research Biography
Dr Grundy is an emerging leader in the field of Neurourology, having established an internationally recognised research program identifying the functional classes of afferents that innervate the bladder, and the channels and receptors underlying their function in health and chronic pain states. Dr Grundy has a proven track record, with high impact publications in journals such as Nature, Pain, JCI insight, Scientific Reports, and the American Journal of Physiology. He also has invited reviews published in Annual Reviews of Physiology, American Journal of Phsyiology, and Frontiers in Autonomic Neuroscience.
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Research output
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Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension
Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N. J., Dong, X., Castro, J., Harrington, A. M. & Brierley, S. M., 28 Apr 2021, In: Journal of Neuroscience. 41, 17, p. 3900-3916 17 p.Research output: Contribution to journal › Article › peer-review
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A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities
Castro, J., Maddern, J., Grundy, L., Manavis, J., Harrington, A. M., Schober, G. & Brierley, S. M., Apr 2021, In: FASEB Journal. 35, 4, 20 p., e21430.Research output: Contribution to journal › Article › peer-review
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A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome
Cardoso, F. C., Castro, J., Grundy, L., Schober, G., Garcia-Caraballo, S., Zhao, T., Herzig, V., King, G. F., Brierley, S. M. & Lewis, R. J., Feb 2021, In: Pain. 162, 2, p. 569-581 13 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Pharmacological modulation of voltage-gated sodium (NaV) channels alters nociception arising from the female reproductive tract
Castro, J., Maddern, J., Erickson, A., Caldwell, A., Grundy, L., Harrington, A. M. & Brierley, S. M., 1 Jan 2021, In: Pain. 162, 1, p. 227-242 16 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Chronic intra-colonic linaclotide administration alters glial activation in a mouse model of chronic visceral hypersensitivity
Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G. & Brierley, S., May 2020, In: Gastroenterology. 158, 6, Supplement 1, p. S-803 1 p., Mo1146 .Research output: Contribution to journal › Meeting Abstract › peer-review