Research Output per year
Research Output per year
Personal profile
Research Biography
Dr Grundy is an emerging leader in the field of Neurourology, having established an internationally recognised research program identifying the functional classes of afferents that innervate the bladder, and the channels and receptors underlying their function in health and chronic pain states. Dr Grundy has a proven track record, with high impact publications in journals such as Nature, Pain, JCI insight, Scientific Reports, and the American Journal of Physiology. He also has invited reviews published in Annual Reviews of Physiology, American Journal of Phsyiology, and Frontiers in Autonomic Neuroscience.
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Research Output
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Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1 receptor and TRPV1
Grundy, L., Caldwell, A., Garcia Caraballo, S., Erickson, A., Schober, G., Castro, J., Harrington, A. M. & Brierley, S. M., Feb 2020, In : American journal of physiology. Renal physiology. 312, 2, p. F298-F314 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Hypersensitivity of bladder low threshold, wide dynamic range, afferent fibres following treatment with the chemotherapeutic drugs cyclophosphamide and ifosfamide
Mills, K. A., West, E. J., Grundy, L., McDermott, C., Sellers, D. J., Rose’Myer, R. B. & Chess-Williams, R., 1 Aug 2020, In : Archives of Toxicology. 94, 8, p. 2785-2797 13 p.Research output: Contribution to journal › Article › peer-review
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Innate immune response to bacterial urinary tract infection sensitises high-threshold bladder afferents and recruits silent nociceptors
Brierley, S. M., Goh, K. G. K., Sullivan, M. J., Moore, K. H., Ulett, G. C. & Grundy, L., Jan 2020, In : Pain. 161, 1, p. 202-210 9 p.Research output: Contribution to journal › Article › peer-review
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Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity
Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., Schober, G., O'Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. W. & Brierley, S. M., 17 Oct 2019, In : JCI insight. 4, 20, e131712.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord
Harrington, A. M., Caraballo, S. G., Maddern, J. E., Grundy, L., Castro, J. & Brierley, S. M., 1 Sep 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 317, 3, p. G285-G303 19 p.Research output: Contribution to journal › Article › peer-review