• 2729 Citations
  • 26 h-Index
1978 …2020

Research output per year

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Personal profile

Research Biography

Prof Pamela Sykes has a PhD in Genetics and has worked in the area of molecular genetics in Australia and the US for over 30 years. Prof Sykes is a Strategic Professor in the area of Preventive Cancer Biology studying the biologiical effects of low doses of ionising radiation. Her research is focussed on studying the protective role of low dose radiation. Some of her current appointments include membership on state and national committees for radiation protection.

Research Interests

Emeritus Prof Pam Sykes retains an interest in low dose radiation research in the following areas but is no longer taking on students as chief supervisor.

  • The temporal response for chromosomal inversions after low dose radiation exposure
  • The effect of known chemical radioprotectors on chromosomal inversion in association with low dose radiation.
  • The effect of low dose radiation on DNA methylation levels
  • The role of radiation induced bystander effects after low dose radiation in vivo
  • Intercellular induced apoptosis as a possible mechanism for low dose radiation induced protection from cancer
  • Effect of low dose radiation on prostate cancer progression in a mouse tumour model

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Research Output

Open Access
  • 3 Citations (Scopus)

    Combination therapies using metformin and/or valproic acid in prostate cancer: Possible mechanistic interactions

    Tran, L. N. K., Kichenadasse, G. & Sykes, P. J., 2019, In : CURRENT CANCER DRUG TARGETS. 19, 5, p. 368-381 14 p.

    Research output: Contribution to journalReview article

  • 2 Citations (Scopus)

    DMAPT is an Effective Radioprotector from Long-Term Radiation-Induced Damage to Normal Mouse Tissues In Vivo

    Morel, K. L., Ormsby, R. J., Klebe, S., Sweeney, C. J. & Sykes, P. J., 1 Aug 2019, In : Radiation Research. 192, 2, p. 231-239 9 p.

    Research output: Contribution to journalArticle

  • 3 Citations (Scopus)

    The combination of metformin and valproic acid has a greater anti-tumoral effect on prostate cancer growth in vivo than either drug alone

    Tran, L. N. K., Kichenadasse, G., Morel, K. L., Lavranos, T. C., Klebe, S., Lower, K. M., Ormsby, R. J., Elliot, D. J. & Sykes, P. J., Jan 2019, In : IN VIVO. 33, 1, p. 99-108 10 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide

    Morel, K., Ormsby, R., Solly, E., Tran, L. N. K., Sweeney, C., Klebe, S., Cordes, N. & Sykes, P., 23 Jun 2018, In : CLINICAL & EXPERIMENTAL METASTASIS. 35, 7, p. 649-661 13 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)