Research output per year
Research output per year
Personal profile
Research Biography
Prof Pamela Sykes has a PhD in Genetics and has worked in the area of molecular genetics in Australia and the US for over 30 years. Prof Sykes is a Strategic Professor in the area of Preventive Cancer Biology studying the biologiical effects of low doses of ionising radiation. Her research is focussed on studying the protective role of low dose radiation. Some of her current appointments include membership on state and national committees for radiation protection.
Research Interests
Emeritus Prof Pam Sykes retains an interest in low dose radiation research in the following areas but is no longer taking on students as chief supervisor.
- The temporal response for chromosomal inversions after low dose radiation exposure
- The effect of known chemical radioprotectors on chromosomal inversion in association with low dose radiation.
- The effect of low dose radiation on DNA methylation levels
- The role of radiation induced bystander effects after low dose radiation in vivo
- Intercellular induced apoptosis as a possible mechanism for low dose radiation induced protection from cancer
- Effect of low dose radiation on prostate cancer progression in a mouse tumour model
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Collaborations and top research areas from the last five years
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Radiation Research Journals Need to Stipulate Minimal Dosimetry Requirements for Publishing Research Using X-Radiation Exposures
Marcu, L. G., Bezak, E. & Sykes, P. J., Aug 2022, In: Radiation Research. 198, 2, p. 204-206 3 p.Research output: Contribution to journal › Comment/debate
1 Citation (Scopus) -
Low Radiation Environment Switches the Overgrowth-Induced Cell Apoptosis Toward Autophagy
Fischietti, M., Fratini, E., Verzella, D., Vecchiotti, D., Capece, D., Di Francesco, B., Esposito, G., Balata, M., Ioannuci, L., Sykes, P., Satta, L., Zazzeroni, F., Tessitore, A., Tabocchini, M. A. & Alesse, E., 12 Jan 2021, In: Frontiers in Public Health. 8, 10 p., 594789.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)7 Downloads (Pure) -
Mutant p53 mediates sensitivity to cancer treatment agents in oesophageal adenocarcinoma associated with microrna and slc7a11 expression
Eichelmann, A-K., Mayne, G. C., Chiam, K., Due, S. L., Bastian, I., Butz, F., Wang, T., Sykes, P. J., Clemons, N. J., Liu, D. S., Michael, M. Z., Karapetis, C. S., Hummel, R., Watson, D. I. & Hussey, D. J., 1 Jun 2021, In: International Journal of Molecular Sciences. 22, 11, 25 p., 5547.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)7 Downloads (Pure) -
DMAPT: A promising new radioprotector
Sykes, P., 2020, In: Radiation Protection in Australasia. 37, 1, p. 3-13 11 p.Research output: Contribution to journal › Article › peer-review
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MicroRNA Profiling in Oesophageal Adenocarcinoma Cell Lines and Patient Serum Samples Reveals a Role for miR-451a in Radiation Resistance
Butz, F., Eichelmann, A-K., Mayne, G., Wang, T., Bastian, I., Chiam, K., Marri, S., Sykes, P. J., Wijnhoven, B. P., Toxopeus, E., Michael, M., Karapetis, C., Hummel, R., Watson, D. I. & Hussey, D., 1 Dec 2020, In: International Journal of Molecular Sciences. 21, 23, p. 1-28 28 p., 8898.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)4 Downloads (Pure)