Research output per year
Research output per year
Personal profile
Research Biography
Professor Mackenzie was awarded a PhD from the University of Sydney (Biochemistry Department, 1976). He held post doctoral positions at the University of Kuopio, Finland (Physiology Department, 1976-1980), National Institutes of Health, Maryland, USA (NICHD, 1980-1987) before returning to Flinders University (Clinical Pharmacology) in 1987 as a NHMRC Research Fellow. He was promoted to Senior Research Fellow in 1991, Principal Research Fellow in 1994 and Senior Principal Research Fellow in 2000. He is currently Emeritus Professor in the Department.
Research Interests
Our defense against the toxic effects of small organic molecules is mediated by families of enzymes found in the internal membranes of cells. Many small organic molecules, such as environmental pollutants, carcinogens and therapeutic drugs, are fat-soluble and will accumulate in the body to toxic levels unless they are modified, usually by the addition of sugar groups. The modified chemical, in the majority of cases, is less toxic and readily removed from the body. We have identified and characterized many of the sugar-transferring enzymes involved in this detoxification process. We are investigating how these enzymes are controlled in the cell and whether there are genetic differences in control processes that may impact on our ability to detoxify drugs and chemicals. This research may provide strategies to help reduce the risk of chemical-induced carcinogenesis and hormone-dependent cancers, such as those of the prostate and breast.
Completed Supervisions
Principal Supervisions:
- Molecular Pharmacology (6)
Associate Supervisions:
- Molecular Pharmacology (10)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Areas
- Medical biosciences
Supervisory Interests
- MicroRNA-regulated gene expression
- Drug metabolising enzymes, cytochrome P450 and UDP-glucuronosyltransferase
- Gene expression
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Collaborations and top research areas from the last five years
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A Comprehensive Bioinformatic Analysis of RNA-seq Datasets Reveals a Differential and Variable Expression of Wildtype and Variant UGT1A Transcripts in Human Tissues and Their Deregulation in Cancers
Hu, D. G., Marri, S., Hulin, J. A., McKinnon, R. A., Mackenzie, P. I. & Meech, R., 13 Jan 2024, In: Cancers. 16, 2, 23 p., 353.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Activation of Cryptic Donor Splice Sites within the UDP-Glucuronosyltransferase (UGT)1A First-Exon Region Generates Variant Transcripts That Encode UGT1A Proteins with Truncated Aglycone-Binding Domains
Hu, D. G., Marri, S., Hulin, J.-A., Ansaar, R., Mackenzie, P. I., McKinnon, R. A. & Meech, R., 1 Jun 2024, In: Drug Metabolism and Disposition. 52, 6, p. 526-538 13 p.Research output: Contribution to journal › Article › peer-review
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Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs
Hu, D. G., Mackenzie, P. I., Hulin, J. A., McKinnon, R. A. & Meech, R., 2022, In: Drug Metabolism Reviews. 54, 2, p. 120-140 21 p.Research output: Contribution to journal › Review article › peer-review
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The Somatic Mutation Landscape of UDP-Glycosyltransferase (UGT) Genes in Human Cancers
Hu, D. G., Marri, S., Hulin, J.-A., McKinnon, R., Mackenzie, P. & Meech, R., 2 Nov 2022, In: Cancers. 14, 22, 28 p., 5708.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4
Miyauchi, Y., Kimura, A., Sawai, M., Fujimoto, K., Hirota, Y., Tanaka, Y., Takechi, S., Mackenzie, P. I. & Ishii, Y., 22 Feb 2022, In: Frontiers in Pharmacology. 13, 10 p., 832931.Research output: Contribution to journal › Article › peer-review
Open AccessFile