• 12040 Citations
  • 58 h-Index
1979 …2020

Research output per year

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Personal profile

Research Biography

Professor Mackenzie was awarded a PhD from the University of Sydney (Biochemistry Department, 1976). He held post doctoral positions at the University of Kuopio, Finland (Physiology Department, 1976-1980), National Institutes of Health, Maryland, USA (NICHD, 1980-1987) before returning to Flinders University (Clinical Pharmacology) in 1987 as a NHMRC Research Fellow. He is currently Emeritus Professor in the Department.

Research Interests

Our defense against the toxic effects of small organic molecules is mediated by families of enzymes found in the internal membranes of cells. Many small organic molecules, such as environmental pollutants, carcinogens and therapeutic drugs, are fat-soluble and will accumulate in the body to toxic levels unless they are modified, usually by the addition of sugar groups. The modified chemical, in the majority of cases, is less toxic and readily removed from the body. We have identified and characterized many of the sugar-transferring enzymes involved in this detoxification process. We are investigating how these enzymes are controlled in the cell and whether there are genetic differences in control processes that may impact on our ability to detoxify drugs and chemicals. This research may provide strategies to help reduce the risk of chemical-induced carcinogenesis and hormone-dependent cancers, such as those of the prostate and breast.

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Research Output

Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT

Miyauchi, Y., Kurita, A., Yamashita, R., Takamatsu, T., Ikushiro, S., Mackenzie, P. I., Tanaka, Y. & Ishii, Y., 30 Apr 2020, In : Biochemical and Biophysical Research Communications. 525, 2, p. 348-353 6 p.

Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression

    Miyauchi, Y., Tanaka, Y., Nagata, K., Yamazoe, Y., Mackenzie, P. I., Yamada, H. & Ishii, Y., Mar 2020, In : British Journal of Pharmacology. 177, 5, p. 1077-1089 13 p.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation

    Liu, Y., Badée, J., Takahashi, R. H., Schmidt, S., Parrott, N., Fowler, S., Mackenzie, P. I., Coughtrie, M. W. H. & Collier, A. C., 26 Dec 2019, In : Journal of Clinical Pharmacology. 60, 6, p. 722-733 12 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)
  • 12 Citations (Scopus)
  • 1 Citation (Scopus)

    Prizes

    Michael Rand Medal

    Mackenzie, Peter (Recipient), 1 Dec 2009

    Prize