Calculated based on number of publications stored in Pure and citations from Scopus
1976 …2024

Research activity per year

Personal profile

Research Biography

Professor Mackenzie was awarded a PhD from the University of Sydney (Biochemistry Department, 1976). He held post doctoral positions at the University of Kuopio, Finland (Physiology Department, 1976-1980), National Institutes of Health, Maryland, USA (NICHD, 1980-1987) before returning to Flinders University (Clinical Pharmacology) in 1987 as a NHMRC Research Fellow. He was promoted to Senior Research Fellow in 1991, Principal Research Fellow in 1994 and Senior Principal Research Fellow in 2000. He is currently Emeritus Professor in the Department.

Research Interests

Our defense against the toxic effects of small organic molecules is mediated by families of enzymes found in the internal membranes of cells. Many small organic molecules, such as environmental pollutants, carcinogens and therapeutic drugs, are fat-soluble and will accumulate in the body to toxic levels unless they are modified, usually by the addition of sugar groups. The modified chemical, in the majority of cases, is less toxic and readily removed from the body. We have identified and characterized many of the sugar-transferring enzymes involved in this detoxification process. We are investigating how these enzymes are controlled in the cell and whether there are genetic differences in control processes that may impact on our ability to detoxify drugs and chemicals. This research may provide strategies to help reduce the risk of chemical-induced carcinogenesis and hormone-dependent cancers, such as those of the prostate and breast.

Completed Supervisions

Principal Supervisions:
  • Molecular Pharmacology (6)
Associate Supervisions:
  • Molecular Pharmacology (10)

Research Areas

  • Medical biosciences

Supervisory Interests

  • MicroRNA-regulated gene expression
  • Drug metabolising enzymes, cytochrome P450 and UDP-glucuronosyltransferase
  • Gene expression


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