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20132022

Research activity per year

Personal profile

Research Interests

My research interests are mainly in the field of marine sponge microbiome. The current running project is €˜unlocking the intracellular microbial endosymbionts of marine sponges for new drug discovery'. Marine sponges contribute over 30% of all marine natural products discovered so far and their associated microbes are considered as the major contributor. We aim to establish the fundamental understanding of sponge intracellular endosymbionts to explore untapped microbial resources for drug development. My focus is to understand endosymbiotic microbiome of different types of sponge cells. The protocols of sponge cultivation, sponge cells dissociation, separation, and purification are developed and optimised. A multi-primer approach (amplicon-based metagenomic sequencing) developed in my PhD is employed to reveal the endosymbiotic microbial profile. The functional pathways indicated by the whole genome analysis of purified sponge cells uncover the relationship between the specific microbiome and their unique secondary metabolite profile. Moreover, I am also interested in the methodology development to isolate the endosymbiotic microbes from sponge cells in the biologically complex holobiont and make them culturable in the laboratory conditions. The secondary metabolites provided by the endosymbionts could be the promising resources of novel bioactive compounds, which are of significant interest to drug discovery due to a growing need for the development of new and potent therapeutic agents.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 9 - Industry, Innovation, and Infrastructure
  • SDG 12 - Responsible Consumption and Production
  • SDG 13 - Climate Action
  • SDG 14 - Life Below Water

Supervision

  • Registered

Research Areas

  • Molecular biosciences

Supervisory Interests

  • Marine microbiology
  • Taxonomy
  • Molecular phylogenetics
  • Sponge-associated bacteria

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