Personal profile
Research Biography
I am a Medical Scientist in the Dept. of Clinical Pharmacology at SAHLN and hold academic status as an Associate Lecturer at Flinders University. My scientific education has started in Italy at the University of Salento where I completed a First level degree in Biotechnology (equivalent to BBiotech and Honours in Organic Chemistry) and Second level degree in Pharmaceutical-industrial Biotechnological Sciences (equivalent to MSc). Following a competitive selection, I was offered a PhD scholarship from the School of Medicine at the Institute of Medical Sciences at the University of Aberdeen, so I moved to Scotland to work on the synthesis of small molecule inhibitiors and the pharmacological modulation of enzymes involved in the nitric oxide pathway under the supervision of Professors Matteo Zanda and Arduino A. Mangoni. As part of my PhD, I spent some time at Flinders University as a visiting students and the network of collaborations formed during this time led me to move definitely to Australia after my Phd conferral in 2015. At Flinders University I worked as a Research Officer (HEO6), first and a Research associate (ResA), later. From February 2020, I took the role of Medical Scientist (MeS2) at SAHLN, but I maintain full academic status at Flinders University, College of Medicine and Public Health, as an Associate Lecturer. My role involves recruiting study participants, arranging study visits and collecting relevant data, developing UPLC-MS based assays, studying the kinetics of enzymes, their substrates and inhibitors, analysis and dissemination of research findings, providing editorial support for publications and conference presentations, developing and enhancing research collaborations, lecturing and providing supervision to students.
I have great dedication and passion for science, strong work ethics and good productivity, and I take pride in my ability to easily build positive professional and personal relationships with patients, clinicians, academics, students and staff.
Education/Academic qualification
PhD, Design and Synthesis of Human Dimethylarginine Dimethylaminohydrolase (DDAH) inhibitors and development of a novel DDAH activity assay, University of Aberdeen
Award Date: 28 Nov 2015
Master of Science, Novel method of one-pot esterification of alcohols and phenols of natural origin, Universita del Salento
Award Date: 14 Dec 2010
Bachelor (Honours), GC-MS and FT-IR analyses of organic residues extracted from archaeological pottery fragments, Universita del Salento
Award Date: 19 Dec 2008
External positions
Medical Scientist, Southern Adelaide Local Health Network
2 Feb 2020 → …
Supervision
- Registered
Keywords
- RM Therapeutics. Pharmacology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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A controlled comparative study of the effects of methotrexate and pharmacogenetic factors on arterial blood pressure and arterial stiffness in patients with rheumatoid arthritis
Mangoni, A. A., Wiese, M. D., Woodman, R. J., Sotgia, S., Zinellu, A., Carru, C., Hulin, J. A., Shanahan, E. M. & Tommasi, S., 2025, In: Annals of Medicine. 57, 1, 15 p., 2539311.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Current knowledge on the mechanisms underpinning vasculogenic mimicry in triple negative breast cancer and the emerging role of nitric oxide
Alemu, B. K., Tommasi, S., Hulin, J.-A., Meyers, J. & Mangoni, A. A., May 2025, In: Biomedicine and Pharmacotherapy. 186, 14 p., 118013.Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Citations (Scopus)57 Downloads (Pure) -
Arginine metabolomics in mood disorders
Zinellu, A., Tommasi, S., Sedda, S. & Mangoni, A. A., 30 Mar 2024, In: Heliyon. 10, 6, 12 p., e27292.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)61 Downloads (Pure) -
A systematic review and meta-analysis of nitric oxide-associated arginine metabolites in schizophrenia
Zinellu, A., Tommasi, S., Carru, C., Sotgia, S. & Mangoni, A. A., 17 Oct 2024, In: Translational Psychiatry. 14, 1, 12 p., 439.Research output: Contribution to journal › Review article › peer-review
Open AccessFile9 Citations (Scopus)154 Downloads (Pure) -
Methotrexate, blood pressure and arterial function in rheumatoid arthritis: study protocol
Mangoni, A. A., Wiese, M. D., Woodman, R. J., Sotgia, S., Zinellu, A., Carru, C., Hulin, J. A., Shanahan, E. M. & Tommasi, S., 10 Oct 2024, In: Future Cardiology. 20, 13, p. 671-683 13 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)