Personal profile
Research Biography
Simon Brookes was awarded his PhD in 1984 for studies on the nervous system of insects. From this he developed a continuing interest in simple neural circuits. He did post-doctoral research in the Royal London Hospital, then moved to Flinders University in 1988. He has been funded by senior research fellowships from the Gastroenterological Society and NHMRC of Australia. In 2005, he was appointed Professor and Head of Human Physiology at Flinders University. Simon's research focusses on how nerve cells work together to give coordinated control of the organs of the body and how they go wrong in disease. His interests range from the molecular level through to the whole organism. He has worked extensively on 'simple' autonomic and sensory pathways to the gut and has published over 110 papers, chapters and reviews. He is convenor of the Centre for Neuroscience
Research Interests
Simon's research interests focus on how nerve cells give rise to sensation and how they control the organs of the body, especially the gastrointestinal tract, ranging from the molecular level through to the behaviour of the whole organism. He has worked extensively on autonomic control of the gut, especially the enteric nervous system and the extrinsic sensory innervation of the bowel. Since his PhD studies, his interests have focussed on "simple" parts of the nervous system where it is possible to understand at the cellular level, how nerve cells work within circuits to give rise to coordinated behaviour. His group has identified the endings of a major class of neurons that mediate pain from the bowel and is attempting to characterise systematically the types of sensory neurons that mediate sensation from the gastrointestinal tract. Simon has a growing interest in how diseases of the Central Nervous System, such as Parkinson's Disease, affect the simpler, more accessible nerves in the periphery.
Completed Supervisions
Principal Supervisions:
- enteric neurons (1)
- Physiology of gut smooth muscle (1)
Associate Supervisions:
- enteric nervous system (1)
Research Areas
- Medical biosciences
Supervisory Interests
- Enteric nervous system
- Sensory neurobiology of the gastrointestinal tract
- Sensory nerves, pain
- Cell biology
- Autonomic nerves, internal organs, blood vessels and skin
- Neuroscience
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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Collaborations and top research areas from the last five years
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The mood stabilizer lithium alters behaviour and physiology via the gut brain axis.
Thorpe, D. W., Ootsuka, Y., Peterson, R. A., Jones, L. A., Humenick, A., Martin, A. M., Zivkovic, J., Sakaguchi, J., McArdle, J., Ittner, A., Brookes, S. J., Habib, A., Sirimaharaj, R., Tawodros, Y., Roach, M., Edwards, R., Clevers, H., Beumer, J., Puschof, J. & Wei, L. & 9 others, , 27 Jan 2026, (Submitted) bioRxiv, Cold Spring Harbor Laboratory, p. 2026.01.26.701868, 36 p.Research output: Working paper/Preprint › Preprint
File10 Downloads (Pure) -
Extrinsic Innervation of Myenteric Plexus of Human Large Intestine Via Colonic Nerves
Humenick, A., Chen, B. N., Johnson, M. E., Yew, W. P., Wattchow, D. A., Sia, T. C., Defontgalland, D., Spencer, N. J., Dinning, P. G., Costa, M. & Brookes, S. J. H., 2025, In: CMGH. 19, 5, 4 p., 101479.Research output: Contribution to journal › Short survey › peer-review
Open AccessFile1 Citation (Scopus)39 Downloads (Pure) -
Gut Neuropathies and Intestinal Motility Disorders
Wattchow, D. A., Brookes, S. J. H., Spencer, N. J., De Giorgio, R., Costa, M. & Dinning, P. G., Aug 2025, In: Neurogastroenterology and Motility. 37, 8, 11 p., e14995.Research output: Contribution to journal › Review article › peer-review
4 Citations (Scopus) -
Marcello Costa (1940–2024)
Brookes, S. J. H., Wattchow, D. A., Spencer, N. J. & Dinning, P. G., 16 Sept 2025, In: Historical Records of Australian Science. 36, 2, 13 p., HR25008.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
A combination of peripherally restricted CB1 and CB2 cannabinoid receptor agonists reduces bladder afferent sensitisation in cystitis
Ramsay, S., Yew, W. P., Brookes, S. & Zagorodnyuk, V., 15 Dec 2024, In: European Journal of Pharmacology. 985, 10 p., 177078.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)47 Downloads (Pure)