Professor Stuart Brierley

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Research Biography

Prof Brierley is an an NHMRC Investigator Leadership Fellow and Matthew Flinders Professor in Gastrointestinal Neuroscience. He is Director of the Visceral Pain Research Group, part of the College of Medicine and Public Health at Flinders University. He is also Director of the Hopwood Centre for Neurobiology at the South Australian Health and Medical Research Institute (SAHMRI).

In 2017 Prof Brierley was awarded an NHMRC Research Excellence Award for being the top Ranked CDF II in the 2016 round. In 2011 Prof Brierley was South Australian Tall Poppy Science Awardee

Prof Brierley is an international leader on the different afferent classes innervating the gut and the bladder, the channels and receptors underlying their function and how this changes in acute and chronic pain. Prof Brierley has a proven track record in coordinating multi-faceted research programs for high-impact publications in journal such as Nature, Cell, Nature Communications, Gastroenterology, Gut, PNAS, JCI Insight, Pain, British Journal of Pharmacology and The Journal of Neuroscience. He also has invited reviews published in Nature Reviews Gastroenterology and Hepatology, Annual Reviews of Physiology, Gut, Trends in Biomedical Sciences, Journal of Physiology and The International Journal of Biochemistry & Cell Biology.

To date, Prof Brierley has been a CI on 13 NHMRC Project grants. He has also been awarded three (2008, 2013, 2016) prestigious NHMRC fellowships. He is CIA on a current NHMRC Development grant and is a CI on an ARC Discovery Grant and CI on 2 recently awarded 3-year NIH grants under the SPARC/HEAL schemes. He also has a strong track record of industry collaboration.

His recent collaborations with Industry partners identified the mechanism of pain relief of a new drug, linaclotide, in treating patient with Irritable Bowel Syndrome with Constipation (IBS-C). Linaclotide, a guanylate cyclase-C (GC-C) agonist is effective in relieving abdominal pain associated with IBS-C and is already available and registered for use by IBS-C patients in the USA and Europe.

For a current list of publications see:

Research Interests

Research Interests

Education/Academic qualification


External positions

Director, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute, South Australian Health and Medical Research Institute

1 Jan 2020 → …

Deputy Director, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute

1 Jan 2019 → …


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