Research output per year
Research output per year
Personal profile
Research Biography
Prof Brierley is an an NHMRC Investigator Leadership Fellow and Matthew Flinders Professor in Gastrointestinal Neuroscience. He is Director of the Visceral Pain Research Group, part of the College of Medicine and Public Health at Flinders University. He is also Director of the Hopwood Centre for Neurobiology at the South Australian Health and Medical Research Institute (SAHMRI).
In 2017 Prof Brierley was awarded an NHMRC Research Excellence Award for being the top Ranked CDF II in the 2016 round. In 2011 Prof Brierley was South Australian Tall Poppy Science Awardee.
Prof Brierley is an international leader on the different afferent classes innervating the gut and the bladder, the channels and receptors underlying their function and how this changes in acute and chronic pain. Prof Brierley has a proven track record in coordinating multi-faceted research programs for high-impact publications in journal such as Nature, Cell, Nature Communications, Gastroenterology, Gut, PNAS, JCI Insight, Pain, British Journal of Pharmacology and The Journal of Neuroscience. He also has invited reviews published in Nature Reviews Gastroenterology and Hepatology, Annual Reviews of Physiology, Gut, Trends in Biomedical Sciences, Journal of Physiology and The International Journal of Biochemistry & Cell Biology.
To date, Prof Brierley has been a CI on 13 NHMRC Project grants. He has also been awarded three (2008, 2013, 2016) prestigious NHMRC fellowships. He is CIA on a current NHMRC Development grant and is a CI on an ARC Discovery Grant and CI on 2 recently awarded 3-year NIH grants under the SPARC/HEAL schemes. He also has a strong track record of industry collaboration.
His recent collaborations with Industry partners identified the mechanism of pain relief of a new drug, linaclotide, in treating patient with Irritable Bowel Syndrome with Constipation (IBS-C). Linaclotide, a guanylate cyclase-C (GC-C) agonist is effective in relieving abdominal pain associated with IBS-C and is already available and registered for use by IBS-C patients in the USA and Europe.
For a current list of publications see: https://www.ncbi.nlm.nih.gov/pubmed/?term=brierley-sm
Research Interests
Research Interests
Education/Academic qualification
PhD
External positions
Director, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute, South Australian Health and Medical Research Institute
1 Jan 2020 → …
Deputy Director, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute
1 Jan 2019 → …
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Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
Osteen, J., Herzig, V., Gilchrist, J., Emrick, J., Zhang, C., Wang, X., Castro, J., Garcia-Caraballo, S., Grundy, L., Rychkov, G., Weyer, A., Dekan, Z., Undheim, E., Alewood, P., Stucky, C., Brierley, S., Basbaum, A., Bosmans, F., King, G. & Julius, D., 6 Jun 2016, In: Nature. 534, 7608, p. 494-499 6 p.Research output: Contribution to journal › Article › peer-review
204 Citations (Scopus) -
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
Bellono, N., Bayrer, J., Leitch, D., Castro, J., Zhang, C., O'Donnell, T., Brierley, S., Ingraham, H. & Julius, D., 29 Jun 2017, In: Cell. 170, 1, p. 185-198 14 p.Research output: Contribution to journal › Article › peer-review
424 Citations (Scopus) -
Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain
de Araujo, A., Mobli, M., Castro Kraftchenko, J., Harrington, A., Vetter, I., Dekan, Z., Muttenthaler, M., Wan, J., Lewis, R., King, G., Brierley, S. & Alewood, P., 30 Jan 2014, In: Nature Communications. 5, p. Art: 3165 12 p., 3165.Research output: Contribution to journal › Article › peer-review
92 Citations (Scopus) -
Neuroplasticity and dysfunction after gastrointestinal inflammation
Brierley, S. & Linden, D., 1 Oct 2014, In: Nature Reviews: Gastroenterology & Hepatology. 11, 10, p. 611-627 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile197 Citations (Scopus)66 Downloads (Pure) -
Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'- monophosphate
Castro, J., Harrington, A., Hughes, P., Martin, C., Ge, P., Shea, C., Jin, H., Jacobson, S., Hannig, G., Mann, E., Cohen, M., MacDougall, J., Lavins, B., Kurtz, C., Silos-Santiago, I., Johnston, J., Currie, M., Blackshaw, L. A. & Brierley, S., Dec 2013, In: Gastroenterology. 145, 6, p. 1334-1346.e11 24 p.Research output: Contribution to journal › Article › peer-review
196 Citations (Scopus)
Prizes
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ARC Discovery Project 2018 DP180101395
Harrington, Andrea (Recipient), Brierley, Stuart (Recipient), Mazzone, Stuart (Recipient) & Rychkov, Grigori (Recipient), 30 Mar 2018
Prize
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NHMRC Project Grant 2019 APP1156427
Spencer, Nick (Recipient), Brierley, Stuart (Recipient), Zagorodnyuk, Vladimir (Recipient) & Harrington, Andrea (Recipient), 2019
Prize
Activities
- 3 Other
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Studies in Mice and Humans Identify Mechanism that Leads to the Pain of Irritable Bowel Syndrome
Stuart Brierley (Participant)
14 Jan 2021Activity: Other activity types › Other
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Solving chronic pain during intercourse
Stuart Brierley (Participant)
3 Feb 2021Activity: Other activity types › Other
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Tarantula venom could hold key to IBS pain relief
Stuart Brierley (Participant)
16 Dec 2020Activity: Other activity types › Other