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Molecular Kill Switch targeting Circular RNAs as a Novel Strategy to Cure (currently) Incurable Childhood Brain Cancer

  • Conn, Simon (Chief Investigator (Project Lead))
  • Beisel, Chase (Chief Investigator)
  • Firestein, Ron (Chief Investigator)
  • Chinnaiyan, Arul M. (Chief Investigator)
  • Diermeier, Sarah (Chief Investigator)
  • Conn, Vanessa (Associate Investigator)
  • Jackson, Ryan (Associate Investigator)
  • Liu, Yang (Associate Investigator)
  • Rizwan, Shakila (Associate Investigator)
  • Jolly, Lachlan (Associate Investigator)
  • University of Wurzburg
  • Hudson Institute of Medical Research, Centre for Cancer Research
  • University of Michigan
  • University of Otago
  • Utah State University
  • University of Utah
  • University of Adelaide

Project Details

Description

I hypothesise that brain cancer-specific circRNAs can be exploited to kill the cells they are expressed in with the CRISPR-Cas12a2 molecular kill switch. My completed project aims to offer a revolutionary improvement in survival of incurable cancers and elevate the therapeutic potential of circRNAs.
StatusActive
Effective start/end date1/03/25 → 28/02/27

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