Precision medicine approaches for JAK2-rearranged ALL: The efficacy of targeted therapies and molecular mechanisms of drug resistance

Toomes, Charlotte (Associate Investigator)
White, Deborah L. (Chief Investigator (Project Lead))
McClure, Barbara (Associate Investigator)
Bruning, John B. (Associate Investigator)

College of Medicine and Public Health

Status	Finished
Effective start/end date	12/03/18 → 31/12/22

7 Poster
2 Article
1 Meeting Abstract
1 Review article

Identification of a novel GOLGA4–JAK2 fusion gene in B-cell acute lymphoblastic leukaemia
Downes, C. E. J., Rehn, J., Heatley, S. L., Yeung, D., McClure, B. J. & White, D. L., Feb 2022, In: British Journal of Haematology. 196, 3, p. 700-705 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Citations (Scopus)
JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies
Downes, C. E. J., McClure, B. J., McDougal, D. P., Heatley, S. L., Bruning, J. B., Thomas, D., Yeung, D. T. & White, D. L., 12 Jul 2022, In: Frontiers in Cell and Developmental Biology. 10, 34 p., 942053.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
29 Citations (Scopus)

213 Downloads (Pure)
Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia
Downes, C. E. J., McClure, B. J., Bruning, J. B., Page, E., Breen, J., Rehn, J., Yeung, D. T. & White, D. L., 10 Aug 2021, In: npj Precision Oncology. 5, 13 p., 75.
Research output: Contribution to journal › Article › peer-review

Open Access
File
21 Citations (Scopus)

56 Downloads (Pure)

ASH Abstract Achievement Award
Downes, C. (Recipient), Dec 2020
Prize
EMBL Australia Post-Graduate Symposium Travel Grant
Downes, C. (Recipient), 2018
Prize
Lorne Cancer Travel Bursary
Downes, C. (Recipient), Feb 2021
Prize