1-Methylxanthine derived from caffeine as a pharmacodynamic probe of oxypurinol effect

D. J. Birkett, J. O. Miners, L. Valente, K. J. Lillywhite, R. O. Day

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aims: In the present study we have investigated the use of caffeine, administered in the form of instant coffee, as a prodrug for 1MX to validate the use of the 1MU:1MX ratio following caffeine administration as a pharmacodynamic measure of oxypurinol effect on xanthine oxidase. Methods: Five healthy volunteers took caffeine 75 mg 8 hourly administered as instant coffee over a 7 day period. They were given allopurinol 600 mg on day 4. Urine was collected in 8 h aliquots from day 1-day 7. The ratio of 1-methyluric acid (1MU) to 1-methylxanthuric (1MX) was determined. Results: The relationship between the plasma oxypurinol (the active metabolite of allopurinol) concentration at the midpoint of each caffeine dosage interval and the decrement in the urinary 1MX to 1MU ratio fitted well by a sigmoid E(max) model. Mean (± s.d.) values of the oxypurinol EC50 (3.9 ± 1.4 mg l-1), EC90 (8.7 ± 1.8 mg l-1) and the exponent, n (3.0 ± 1.2) were similar to those obtained previously following either the direct administration of 1MX or the use of theophylline as a prodrug for 1MX. Conclusions: These data indicate that the use of caffeine as a source of 1MX could provide a simple and ethically acceptable method for monitoring oxypurinol effect in patients taking allopurinol for the treatment of gout.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume43
Issue number2
DOIs
Publication statusPublished - Feb 1997
Externally publishedYes

Keywords

  • 1-Methylxanthine
  • Allopurinol
  • Caffeine
  • Oxypurinol
  • Pharmacodynamics
  • Xanthine oxidase

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