1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate analogues modified at C-3; synthesis of 1D-3-C-(trifluoromethyl)-myo-inositol 1,4,5-trisphosphate and 1L-chiro-insitol 1,2,3,5-tetrakisphosphate from L-quebrachitol

Alan P. Kozikowski, Vassil I. Ognyanov, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The novel 3-modified 1D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P 3] analogues 1D-3-C-(trifluoromethyl)-myo-inositol 1,4,5-trisphosphate and 1L-chiro-inositol 1,2,3,5-tetrakisphosphate are synthesized from L-quebrachitol, and the preliminary results on their Ca 2+ releasing activity suggest that the Ins(1,4,5)P3 receptor can accommodate some steric bulk in the axial region of the 3-position of Ins(1,4,5)P3 when the equatorial 3-hydroxy group is retained.

Original languageEnglish
Pages (from-to)599-600
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number5
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint Dive into the research topics of '1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate analogues modified at C-3; synthesis of 1D-3-C-(trifluoromethyl)-myo-inositol 1,4,5-trisphosphate and 1L-chiro-insitol 1,2,3,5-tetrakisphosphate from L-quebrachitol'. Together they form a unique fingerprint.

Cite this