1‐Methylxanthine derived from theophylline as an in vivo biochemical probe of allopurinol effect.

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    Abstract

    The urinary 1‐methyluric acid (1MU) to 1‐methylxanthine (1MX) ratio has been assessed as a biochemical index of oxipurinol effect in vivo in man. Dosing with theophylline was used to produce 1MX as an intermediate metabolite in six healthy volunteers. A sigmoid Emax model was fitted to the data and gave a mean plasma oxipurinol IC50 of 3.0 +/‐ 1.1 mg l‐1, a mean exponent n of 3.4 +/‐ 2.1 and a mean IC90 of 8.5 +/‐ 5.9 mg l‐1. There was marked interindividual variability in the steepness of the plasma oxipurinol concentration response relationship, and in the plasma oxipurinol IC90 values. The study has confirmed the feasibility of using single doses of allopurinol to construct individual plasma oxipurinol concentration‐response curves. 1991 The British Pharmacological Society

    Original languageEnglish
    Pages (from-to)238-241
    Number of pages4
    JournalBritish Journal of Clinical Pharmacology
    Volume32
    Issue number2
    DOIs
    Publication statusPublished - Aug 1991

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