A biclonal case of chronic lymphocytic leukaemia with discordant mutational status of the immunoglobulin heavy chain variable region and bimodal CD49d expression

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Abstract

An 87-year-old man with multiple medical comorbidities presented to the haematology clinic in April of 2013 with a six-month history of anorexia, weight loss, progressive anaemia and lymphocytosis. On examination, splenomegaly and small volume widespread lymphadenopathy was observed. The initial blood results showed...
Original languageEnglish
Pages (from-to)e77-e81
Number of pages4
JournalBritish Journal of Haematology
Volume192
Issue number3
Early online date5 Dec 2020
DOIs
Publication statusPublished - Feb 2021

Keywords

  • CLL
  • clonal architecture
  • IGHV
  • trisomy 12
  • whole-exome sequencing

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