A biclonal case of chronic lymphocytic leukaemia with discordant mutational status of the immunoglobulin heavy chain variable region and bimodal CD49d expression

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Abstract

An 87-year-old man with multiple medical comorbidities presented to the haematology clinic in April of 2013 with a six-month history of anorexia, weight loss, progressive anaemia and lymphocytosis. On examination, splenomegaly and small volume widespread lymphadenopathy was observed. The initial blood results showed...
Original languageEnglish
Number of pages4
JournalBritish Journal of Haematology
Early online date5 Dec 2020
DOIs
Publication statusE-pub ahead of print - 5 Dec 2020

Keywords

  • CLL
  • clonal architecture
  • IGHV
  • trisomy 12
  • whole-exome sequencing

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