A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

Steve Pedrini, Veer Bala Gupta, Eugene Hone, James D. Doecke, Sid E. O'Bryant, Ian R. James, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David J. Ames, Colin L. Masters, Ralph N. Martins, AIBL Research Group, Gregory R. Savage, Bill Wilson, Pierrick T. Bourgeat, Jürgen Fripp, Simon Gibson, Hugo Leroux, Simon J. McBrideOlivier Salvado, Michael Felix Fenech, Maxime François, Mary B. Barnes, Jenalle E. Baker, Kevin Jeffrey Barnham, Shayne A. Bellingham, Julia Bomke, Svetlana Bozin Pejoska, Rachel F. Buckley, Lesley Cheng, Steven John Collins, Ian Cooke, Elizabeth V. Cyarto, David G. Darby, Vincent Doré, Denise El-Sheikh, Noel G. Faux, Christopher J. Fowler, Karra D. Harrington, Andrew F. Hill, Malcolm Kenneth Horne, Gareth R. Jones, Adrian Kamer, Neil Killeen, Hannah Korrel, Fiona Lamb, Nicola T. Lautenschlager, Kate Lennon, Qiaoxin Li, Yen Ying Lim, Andrea G. Louey, Lance S. Macaulay, Lucy Mackintosh, Paul T. Maruff, Alissandra M. McIlroy, Julie Nigro, Keyla A. Perez, Kelly Kathleen Pertile, Carolina Restrepo, Barbara Rita Cardoso, Alan R. Rembach, Blaine R. Roberts, Joanne S. Robertson, Rebecca L. Rumble, Timothy M. Ryan, Jack Sach, Brendan S. Silbert, Christine Thai, Brett O. Trounson, Irene Volitakis, Michael Vovos, Larry Ward, Andrew D. Watt, Robert Williams, Michael Clifford Woodward., Paul A. Yates, Fernanda Yevenes Ugarte, Ping Zhang, Sabine M. Bird, Belinda Brown, Samantha C. Burnham, Pratishtha Chatterjee, Kay L. Cox, Shane Fernandez, Warnakulasuriya M.A.D.B. Fernando, Samantha L. Gardener, Simon M. Laws, Florence Lim, Lucy Lim, Michelle L. Tegg, Kathy Lucas, Georgia Martins, Tenielle Porter, Stephanie R. Rainey-Smith, Mark A. Rodrigues, Kaikai Shen, Hamid R. Sohrabi, Kevin Taddei, Tania Taddei, Sherilyn Tan, Giuseppe Verdile, Michael Weinborn, Maree Farrow, Shaun M. Frost, David Hanson, Maryam Hor, Yogesan Kanagasingam, Wayne Richard Leifert, Linda Jane Lockett, Malcolm Riley, Ian W. Saunders, Philip Thomas

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Abstract

Alzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ϵ4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ϵ4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD and/or early stage AD for which current therapies may be more beneficial.

Original languageEnglish
Article number14057
Number of pages12
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 25 Oct 2017
Externally publishedYes

Bibliographical note

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