A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates

Elizabeth Grayson, Goncalo Bernardes, Justin Chalker, Omar Boutureira, Julia Koeppe, Benjamin Davis

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    A sweet solution: A strategy for the synthesis of well-defined carbohydrate-based vaccines is presented. The approach couples complex oligosaccharide synthesis to site-specific conjugation methodology to provide pure glycoprotein vaccine candidates (see scheme).

    Original languageEnglish
    Pages (from-to)4127-4132
    Number of pages6
    JournalAngewandte Chemie-International Edition
    Volume50
    Issue number18
    DOIs
    Publication statusPublished - 26 Apr 2011

    Keywords

    • disulfide donors
    • glycosylation
    • oligosaccharides
    • protein conjugation
    • vaccines

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