A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates

Elizabeth Grayson; Goncalo Bernardes; Justin Chalker; Omar Boutureira; Julia Koeppe; Benjamin Davis

doi:10.1002/anie.201006327

A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates

Elizabeth Grayson, Goncalo Bernardes, Justin Chalker, Omar Boutureira, Julia Koeppe, Benjamin Davis

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

A sweet solution: A strategy for the synthesis of well-defined carbohydrate-based vaccines is presented. The approach couples complex oligosaccharide synthesis to site-specific conjugation methodology to provide pure glycoprotein vaccine candidates (see scheme).

Original language	English
Pages (from-to)	4127-4132
Number of pages	6
Journal	Angewandte Chemie-International Edition
Volume	50
Issue number	18
DOIs	https://doi.org/10.1002/anie.201006327
Publication status	Published - 26 Apr 2011

Keywords

disulfide donors
glycosylation
oligosaccharides
protein conjugation
vaccines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201006327

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title = "A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates",

abstract = "A sweet solution: A strategy for the synthesis of well-defined carbohydrate-based vaccines is presented. The approach couples complex oligosaccharide synthesis to site-specific conjugation methodology to provide pure glycoprotein vaccine candidates (see scheme).",

keywords = "disulfide donors, glycosylation, oligosaccharides, protein conjugation, vaccines",

author = "Elizabeth Grayson and Goncalo Bernardes and Justin Chalker and Omar Boutureira and Julia Koeppe and Benjamin Davis",

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AU - Grayson, Elizabeth

AU - Bernardes, Goncalo

AU - Chalker, Justin

AU - Boutureira, Omar

AU - Koeppe, Julia

AU - Davis, Benjamin

PY - 2011/4/26

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AB - A sweet solution: A strategy for the synthesis of well-defined carbohydrate-based vaccines is presented. The approach couples complex oligosaccharide synthesis to site-specific conjugation methodology to provide pure glycoprotein vaccine candidates (see scheme).

KW - disulfide donors

KW - glycosylation

KW - oligosaccharides

KW - protein conjugation

KW - vaccines

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U2 - 10.1002/anie.201006327

DO - 10.1002/anie.201006327

M3 - Article

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JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

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ER -

A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates

Abstract

Keywords

UN SDGs

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