TY - JOUR
T1 - A decade of FRAX
T2 - how has it changed the management of osteoporosis?
AU - Kanis, John A.
AU - Harvey, Nicholas C.
AU - Johansson, Helena
AU - Liu, Enwu
AU - Vandenput, Liesbeth
AU - Lorentzon, Mattias
AU - Leslie, William D.
AU - McCloskey, Eugene V.
PY - 2020/2/12
Y1 - 2020/2/12
N2 - The fracture risk assessment tool, FRAX®, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. The application of FRAX in assessment guidelines has been heterogeneous with the adoption of several different approaches in setting intervention thresholds. Whereas most guidelines adopt a case-finding strategy, the case for FRAX-based community screening in the elderly is increasing. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future.
AB - The fracture risk assessment tool, FRAX®, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. The application of FRAX in assessment guidelines has been heterogeneous with the adoption of several different approaches in setting intervention thresholds. Whereas most guidelines adopt a case-finding strategy, the case for FRAX-based community screening in the elderly is increasing. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future.
KW - Clinical risk factors
KW - Fracture probability
KW - FRAX
KW - Intervention thresholds
KW - Risk assessment
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=85079435958&partnerID=8YFLogxK
U2 - 10.1007/s40520-019-01432-y
DO - 10.1007/s40520-019-01432-y
M3 - Review article
C2 - 32043227
AN - SCOPUS:85079435958
SN - 1594-0667
VL - 32
SP - 187
EP - 196
JO - Aging Clinical and Experimental Research
JF - Aging Clinical and Experimental Research
IS - 2
ER -