A diagnosis of the primary difference between EuroForMix and STRmix™

John Buckleton; Mateusz Susik; James M. Curran; Kevin Cheng; Duncan Taylor; Jo Anne Bright; Hannah Kelly; Richard Wivell

doi:10.1111/1556-4029.15387

A diagnosis of the primary difference between EuroForMix and STRmix™

John Buckleton, Mateusz Susik, James M. Curran, Kevin Cheng, Duncan Taylor, Jo Anne Bright, Hannah Kelly, Richard Wivell

College of Science and Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

There is interest in comparing the output, principally the likelihood ratio, from the two probabilistic genotyping software EuroForMix (EFM) and STRmix™. Many of these comparison studies are descriptive and make little or no effort to diagnose the cause of difference. There are fundamental differences between EFM and STRmix™ that are causative of the largest set of likelihood ratio differences. This set of differences is for false donors where there are many instances of LRs just above or below 1 for EFM that give much lower LRs in STRmix™. This is caused by the separate estimation of parameters such as allele height variance and mixture proportion using MLE under H_p and H_a for EFM. This can result in very different estimations of these parameters under H_p and H_a. It results in a departure from calibration for EFM in the region of LRs just above and below 1.

Original language	English
Pages (from-to)	40-51
Number of pages	12
Journal	Journal of Forensic Sciences
Volume	69
Issue number	1
Early online date	27 Sept 2023
DOIs	https://doi.org/10.1111/1556-4029.15387
Publication status	Published - Jan 2024

Keywords

EuroForMix
forensic DNA
probabilistic genotyping
reliability
STRmix™
validation

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abstract = "There is interest in comparing the output, principally the likelihood ratio, from the two probabilistic genotyping software EuroForMix (EFM) and STRmix{\texttrademark}. Many of these comparison studies are descriptive and make little or no effort to diagnose the cause of difference. There are fundamental differences between EFM and STRmix{\texttrademark} that are causative of the largest set of likelihood ratio differences. This set of differences is for false donors where there are many instances of LRs just above or below 1 for EFM that give much lower LRs in STRmix{\texttrademark}. This is caused by the separate estimation of parameters such as allele height variance and mixture proportion using MLE under Hp and Ha for EFM. This can result in very different estimations of these parameters under Hp and Ha. It results in a departure from calibration for EFM in the region of LRs just above and below 1.",

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AU - Bright, Jo Anne

AU - Kelly, Hannah

AU - Wivell, Richard

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A diagnosis of the primary difference between EuroForMix and STRmix™

Abstract

Keywords

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