A fluorescent and solvatochromic 1,8-naphthalimide probe for detection of lipid droplet trafficking and biogenesis

Shane M. Hickey, Ian R. D. Johnson, Elena Dallerba, Mark J. Hackett, Massimiliano Massi, Joanna Lazniewska, Lauren A. Thurgood, Frederick M. Pfeffer, Douglas A. Brooks, Trent D. Ashton

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We present a highly fluorescent, solvatochromic, 1,8-naphthalimide for simultaneous imaging of lipid droplets and endoplasmic reticulum, with distinguishable emission maxima. By delineating organelles based on their emission profiles, lipid droplet biogenesis and intercellular trafficking events are visualised. The probe also stains myelin lipids in ex vivo brain tissue, indicating histochemical applications.

Original languageEnglish
Article number111382
Number of pages6
JournalDYES AND PIGMENTS
Volume217
Early online date5 May 2023
DOIs
Publication statusPublished - Sept 2023

Keywords

  • Lipids
  • 1,8-naphthalimide
  • intercellular trafficking events

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