A fully continuous system of DNA profile evidence evaluation that can utilise STR profile data produced under different conditions within a single analysis

Duncan Taylor, Jo Anne Bright, Hannah Kelly, Meng Han Lin, John Buckleton

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The introduction of probabilistic DNA interpretation systems has made it possible to evaluate many profiles that previously (under a manual interpretation system) were not. These probabilistic systems have been around for a number of years and it is becoming more common that their use within a laboratory has spanned at least one technology change. This may be a change in laboratory hardware, the DNA profiling kit used, or the manner in which the profile is generated. Up until this point, when replicates DNA profiles are generated, that span a technological change, the ability to utilise all the information in all replicates has been limited or non-existent. In this work we explain and derive the models required to evaluate (what we term) multi-kit analysis problems. We demonstrate the use of the multi-kit feature on a number of scenarios where such an analysis would be desired within a laboratory. Allowing the combination of profiling data that spans a technological change will further increase the amount of DNA profile information produced in a laboratory that can be evaluated.

    Original languageEnglish
    Pages (from-to)149-154
    Number of pages6
    JournalForensic Science International: Genetics
    Volume31
    DOIs
    Publication statusPublished - Nov 2017

    Keywords

    • Continuous DNA interpretation
    • DNA mixtures
    • Modelling
    • Multiple DNA profiling kits
    • STRmix

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