TY - JOUR
T1 - A Green and Convenient Route for the Regioselective Synthesis of New Substituted 3-Aryl-5H-indeno[1,2-c]pyridazines as Potential Monoamine Oxidase Type A Inhibitors
AU - Rimaz, Mehdi
AU - Aali, Farkhondeh
AU - Khalili, Behzad
AU - Prager, Rolf H
PY - 2017/6
Y1 - 2017/6
N2 - Several indeno[1,2-c]pyridazines were efficiently synthesised using the one-pot, three-component reaction of substituted indanones, arylglyoxalmonohydrates, and hydrazine in the presence of 1,5-diazabicyclo[4,3,0]non-5-ene (DBN) in water at room temperature. These substituted 3-aryl indeno[1,2-c]pyridazines can be considered as potential monoamine oxidase type A (MAOA) inhibitors. The advantages of this new strategy are the novelty of the indenopyridazine derivatives, high regioselectivity, use of water as the solvent, no requirement for toxic metal catalysts, and good to excellent yields.
AB - Several indeno[1,2-c]pyridazines were efficiently synthesised using the one-pot, three-component reaction of substituted indanones, arylglyoxalmonohydrates, and hydrazine in the presence of 1,5-diazabicyclo[4,3,0]non-5-ene (DBN) in water at room temperature. These substituted 3-aryl indeno[1,2-c]pyridazines can be considered as potential monoamine oxidase type A (MAOA) inhibitors. The advantages of this new strategy are the novelty of the indenopyridazine derivatives, high regioselectivity, use of water as the solvent, no requirement for toxic metal catalysts, and good to excellent yields.
KW - Pyridazine
KW - Monoamino oxidases
KW - Indenopyridazine
UR - http://www.scopus.com/inward/record.url?scp=85019955074&partnerID=8YFLogxK
U2 - 10.1071/CH16364
DO - 10.1071/CH16364
M3 - Article
AN - SCOPUS:85019955074
SN - 0004-9425
VL - 70
SP - 660
EP - 668
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
IS - 6
ER -