A Green and Convenient Route for the Regioselective Synthesis of New Substituted 3-Aryl-5H-indeno[1,2-c]pyridazines as Potential Monoamine Oxidase Type A Inhibitors

Mehdi Rimaz, Farkhondeh Aali, Behzad Khalili, Rolf H Prager

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Several indeno[1,2-c]pyridazines were efficiently synthesised using the one-pot, three-component reaction of substituted indanones, arylglyoxalmonohydrates, and hydrazine in the presence of 1,5-diazabicyclo[4,3,0]non-5-ene (DBN) in water at room temperature. These substituted 3-aryl indeno[1,2-c]pyridazines can be considered as potential monoamine oxidase type A (MAOA) inhibitors. The advantages of this new strategy are the novelty of the indenopyridazine derivatives, high regioselectivity, use of water as the solvent, no requirement for toxic metal catalysts, and good to excellent yields.

Original languageEnglish
Pages (from-to)660-668
Number of pages9
JournalAustralian Journal of Chemistry
Volume70
Issue number6
Early online date12 Oct 2016
DOIs
Publication statusPublished - Jun 2017

Keywords

  • Pyridazine
  • Monoamino oxidases
  • Indenopyridazine

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