TY - JOUR
T1 - A guide to missing data for the pediatric nephrologist
AU - Larkins, Nicholas G.
AU - Craig, Jonathan C.
AU - Teixeira-Pinto, Armando
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Missing data is an important and common source of bias in clinical research. Readers should be alert to and consider the impact of missing data when reading studies. Beyond preventing missing data in the first place, through good study design and conduct, there are different strategies available to handle data containing missing observations. Complete case analysis is often biased unless data are missing completely at random. Better methods of handling missing data include multiple imputation and models using likelihood-based estimation. With advancing computing power and modern statistical software, these methods are within the reach of clinician-researchers under guidance of a biostatistician. As clinicians reading papers, we need to continue to update our understanding of statistical methods, so that we understand the limitations of these techniques and can critically interpret literature.
AB - Missing data is an important and common source of bias in clinical research. Readers should be alert to and consider the impact of missing data when reading studies. Beyond preventing missing data in the first place, through good study design and conduct, there are different strategies available to handle data containing missing observations. Complete case analysis is often biased unless data are missing completely at random. Better methods of handling missing data include multiple imputation and models using likelihood-based estimation. With advancing computing power and modern statistical software, these methods are within the reach of clinician-researchers under guidance of a biostatistician. As clinicians reading papers, we need to continue to update our understanding of statistical methods, so that we understand the limitations of these techniques and can critically interpret literature.
KW - Epidemiology
KW - Multiple imputation
KW - Nephrology
KW - Statistics
UR - http://www.scopus.com/inward/record.url?scp=85043688535&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1092957
UR - http://purl.org/au-research/grants/NHMRC/1114218
U2 - 10.1007/s00467-018-3932-4
DO - 10.1007/s00467-018-3932-4
M3 - Article
C2 - 29536258
VL - 34
SP - 223
EP - 231
JO - PEDIATRIC NEPHROLOGY
JF - PEDIATRIC NEPHROLOGY
SN - 0931-041X
IS - 2
ER -