A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects

Cameron Holloway, Cochlin Lowri, Yaso Emmanuel, Andrew Murray, Ion Codreanu, Lindsay Edwards, Cezary Szmigielski, Damian Tyler, Nicholas Knight, Brian Saxby, Bridget Lambert, Campbell Thompson, Stefan Neubauer, Kieran Clarke

    Research output: Contribution to journalArticlepeer-review

    88 Citations (Scopus)


    Background: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations. Objective: We tested whether raising plasma free fatty acids by using a high-fat, low-carbohydrate diet results in alterations in heart and brain in healthy subjects. Design: Men (n = 16) aged 22 ± 1 y (mean ± SE) were randomly assigned to 5 d of a high-fat, low-carbohydrate diet containing 75 ± 1% of calorie intake through fat consumption or to an isocaloric standard diet providing 23 ± 1% of calorie intake as fat. In a crossover design, subjects undertook the alternate diet after a 2-wk washout period, with results compared after the diet periods. Cardiac 31P magnetic resonance (MR) spectroscopy and MR imaging, echocardiography, and computerized cognitive tests were used to assess cardiac phosphocreatine (PCr)/ATP, cardiac function, and cognitive function, respectively. Results: Compared with the standard diet, subjects who consumed the high-fat, low-carbohydrate diet had 44% higher plasma free fatty acids (P < 0.05), 9% lower cardiac PCr/ATP (P < 0.01), and no change in cardiac function. Cognitive tests showed impaired attention (P < 0.01), speed (P < 0.001), and mood (P < 0.01) after the high-fat, low-carbohydrate diet. Conclusion: Raising plasma free fatty acids decreased myocardial PCr/ATP and reduced cognition, which suggests that a high-fat diet is detrimental to heart and brain in healthy subjects.

    Original languageEnglish
    Pages (from-to)748-755
    Number of pages8
    JournalAmerican Journal of Clinical Nutrition
    Issue number4
    Publication statusPublished - 1 Apr 2011

    Fingerprint Dive into the research topics of 'A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects'. Together they form a unique fingerprint.

    Cite this