A meta-analysis of sperm donation offspring health outcomes

Damian Adams, Robyn Clark, Michael Davies, Sheryl de Lacey

    Research output: Contribution to journalReview articlepeer-review

    12 Citations (Scopus)


    Although the use of donor sperm as a treatment modality for male infertility has become common place, the health outcomes for those conceived has been poorly studied. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the health outcomes of offspring conceived from donor sperm. Eight studies were eligible and included in the review, and of these, three were included in a meta-analysis. Meta-analysis of clinical outcomes showed that donor sperm neonates are not at increased risk of being born of low birth weight (<2500 g), preterm (<37 weeks) or with increased incidences of birth defects, than spontaneously conceived neonates.

    Original languageEnglish
    Pages (from-to)44-55
    Number of pages12
    JournalJournal of Developmental Origins of Health and Disease
    Issue number1
    Publication statusPublished - 1 Feb 2017


    • Donor conception
    • meta-analysis
    • neonate
    • outcome
    • sperm


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