A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis

Hazem J. Abuhusain; Azadeh Matin; Qiao Qiao; Han Shen; Nupur Kain; Bryan W. Day; Brett W. Stringer; Benjamin Daniels; Maarit A. Laaksonen; Charlie Teo; Kerrie L. McDonald; Anthony S. Don

doi:10.1074/jbc.M113.494740

A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis

Hazem J. Abuhusain, Azadeh Matin, Qiao Qiao, Han Shen, Nupur Kain, Bryan W. Day, Brett W. Stringer, Benjamin Daniels, Maarit A. Laaksonen, Charlie Teo, Kerrie L. McDonald, Anthony S. Don

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Background: The sphingolipid metabolite sphingosine 1-phosphate (S1P) is a potent angiogenic factor. Results: S1P content is 9-fold higher in glioblastomas compared with normal brain, and S1P production is necessary for glioblastoma cells to trigger endothelial cell angiogenesis. Conclusion: Excessive S1P synthesis is a major contributor to glioblastoma angiogenesis. Significance: Inhibiting S1P synthesis may be a valuable antiangiogenic approach in glioblastoma.

Original language	English
Pages (from-to)	37355-37364
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M113.494740
Publication status	Published - 27 Dec 2013
Externally published	Yes

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Abuhusain, H. J., Matin, A., Qiao, Q., Shen, H., Kain, N., Day, B. W., Stringer, B. W., Daniels, B., Laaksonen, M. A., Teo, C., McDonald, K. L., & Don, A. S. (2013). A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. Journal of Biological Chemistry, 288(52), 37355-37364. https://doi.org/10.1074/jbc.M113.494740

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title = "A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis",

abstract = "Background: The sphingolipid metabolite sphingosine 1-phosphate (S1P) is a potent angiogenic factor. Results: S1P content is 9-fold higher in glioblastomas compared with normal brain, and S1P production is necessary for glioblastoma cells to trigger endothelial cell angiogenesis. Conclusion: Excessive S1P synthesis is a major contributor to glioblastoma angiogenesis. Significance: Inhibiting S1P synthesis may be a valuable antiangiogenic approach in glioblastoma.",

author = "Abuhusain, {Hazem J.} and Azadeh Matin and Qiao Qiao and Han Shen and Nupur Kain and Day, {Bryan W.} and Stringer, {Brett W.} and Benjamin Daniels and Laaksonen, {Maarit A.} and Charlie Teo and McDonald, {Kerrie L.} and Don, {Anthony S.}",

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month = dec,

day = "27",

doi = "10.1074/jbc.M113.494740",

language = "English",

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T1 - A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis

AU - Abuhusain, Hazem J.

AU - Matin, Azadeh

AU - Qiao, Qiao

AU - Shen, Han

AU - Kain, Nupur

AU - Day, Bryan W.

AU - Stringer, Brett W.

AU - Daniels, Benjamin

AU - Laaksonen, Maarit A.

AU - Teo, Charlie

AU - McDonald, Kerrie L.

AU - Don, Anthony S.

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: The sphingolipid metabolite sphingosine 1-phosphate (S1P) is a potent angiogenic factor. Results: S1P content is 9-fold higher in glioblastomas compared with normal brain, and S1P production is necessary for glioblastoma cells to trigger endothelial cell angiogenesis. Conclusion: Excessive S1P synthesis is a major contributor to glioblastoma angiogenesis. Significance: Inhibiting S1P synthesis may be a valuable antiangiogenic approach in glioblastoma.

AB - Background: The sphingolipid metabolite sphingosine 1-phosphate (S1P) is a potent angiogenic factor. Results: S1P content is 9-fold higher in glioblastomas compared with normal brain, and S1P production is necessary for glioblastoma cells to trigger endothelial cell angiogenesis. Conclusion: Excessive S1P synthesis is a major contributor to glioblastoma angiogenesis. Significance: Inhibiting S1P synthesis may be a valuable antiangiogenic approach in glioblastoma.

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U2 - 10.1074/jbc.M113.494740

DO - 10.1074/jbc.M113.494740

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SP - 37355

EP - 37364

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 52

ER -

A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis

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