A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis

Hazem J. Abuhusain, Azadeh Matin, Qiao Qiao, Han Shen, Nupur Kain, Bryan W. Day, Brett W. Stringer, Benjamin Daniels, Maarit A. Laaksonen, Charlie Teo, Kerrie L. McDonald, Anthony S. Don

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Abstract

Background: The sphingolipid metabolite sphingosine 1-phosphate (S1P) is a potent angiogenic factor. Results: S1P content is 9-fold higher in glioblastomas compared with normal brain, and S1P production is necessary for glioblastoma cells to trigger endothelial cell angiogenesis. Conclusion: Excessive S1P synthesis is a major contributor to glioblastoma angiogenesis. Significance: Inhibiting S1P synthesis may be a valuable antiangiogenic approach in glioblastoma.

Original languageEnglish
Pages (from-to)37355-37364
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
Publication statusPublished - 27 Dec 2013
Externally publishedYes

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  • Cite this

    Abuhusain, H. J., Matin, A., Qiao, Q., Shen, H., Kain, N., Day, B. W., Stringer, B. W., Daniels, B., Laaksonen, M. A., Teo, C., McDonald, K. L., & Don, A. S. (2013). A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. Journal of Biological Chemistry, 288(52), 37355-37364. https://doi.org/10.1074/jbc.M113.494740