A modified synthesis of (Z)-pyrethrolone

Todd E. Markham, Peter J. Duggan, Martin R. Johnston

Research output: Contribution to journalArticlepeer-review

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An accessible, efficient, and reliable synthesis for the production of (Z)-pyrethrolone remains necessary as previous syntheses suffer from drawbacks including the use of toxic reagents, expensive starting materials and lack of regioselectivity in the production of key intermediates. This work attempts to alleviate the issues of prior syntheses by making use of well-known and regioselective transformations for the efficient synthesis of (Z)-pyrethrolone. Ultimately, (Z)-pyrethrolone is generated in an overall 20% yield over five steps from a cheap, easily accessible starting material using reliable, optimised transformations.

Original languageEnglish
Pages (from-to)99-109
Number of pages11
Issue number4
Publication statusPublished - 3 Feb 2022


  • Natural product
  • Pyrethrolone
  • Regioselective synthesis


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