A new frontier for nondestructive spatial analysis of pharmaceutical solid dosage forms:: Spatially offset low-frequency Raman spectroscopy

Ka̅rlis Be̅rziņš; Sara J. Fraser-Miller; Keith C. Gordon

doi:10.1021/acs.analchem.0c04960

A new frontier for nondestructive spatial analysis of pharmaceutical solid dosage forms: Spatially offset low-frequency Raman spectroscopy

Ka̅rlis Be̅rziņš, Sara J. Fraser-Miller, Keith C. Gordon

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A new Raman subtechnique, spatially offset low-frequency Raman spectroscopy (SOLFRS), is demonstrated via an analysis of pharmaceutical solid dosage forms. Several different model systems comprised of celecoxib (a popular anti-inflammatory drug), α-lactose anhydrous stable form, α-lactose monohydrate, and polyvinylpyrrolidone (PVP) were used to represent tangible scenarios for the application of SOLFRS. Additionally, the challenges and limitations were highlighted in relation to its real-time use, and potential solutions to address them were also provided. Lastly, the future directions for this new variation of Raman spectroscopic technique were briefly discussed, including its potential for broader application in pharmaceutical analysis and other research fields.

Original language	English
Pages (from-to)	3698-3705
Number of pages	8
Journal	Analytical Chemistry
Volume	93
Issue number	8
DOIs	https://doi.org/10.1021/acs.analchem.0c04960
Publication status	Published - 2 Mar 2021
Externally published	Yes

Keywords

Raman spectroscopy
Sugars
Alpha lactose monohydrate
Anti-inflammatory drugs
Low-frequency Raman spectroscopy
Pharmaceutical analysis
Polyvinyl pyrrolidone
Raman spectroscopic
Solid dosage forms
Spatial analysis
Spectroscopic analysis

Access to Document

10.1021/acs.analchem.0c04960Licence: In Copyright

Cite this

@article{79cca238e7ce41c1a2d5ec08e29c520a,

title = "A new frontier for nondestructive spatial analysis of pharmaceutical solid dosage forms:: Spatially offset low-frequency Raman spectroscopy",

abstract = "A new Raman subtechnique, spatially offset low-frequency Raman spectroscopy (SOLFRS), is demonstrated via an analysis of pharmaceutical solid dosage forms. Several different model systems comprised of celecoxib (a popular anti-inflammatory drug), α-lactose anhydrous stable form, α-lactose monohydrate, and polyvinylpyrrolidone (PVP) were used to represent tangible scenarios for the application of SOLFRS. Additionally, the challenges and limitations were highlighted in relation to its real-time use, and potential solutions to address them were also provided. Lastly, the future directions for this new variation of Raman spectroscopic technique were briefly discussed, including its potential for broader application in pharmaceutical analysis and other research fields.",

keywords = "Raman spectroscopy, Sugars, Alpha lactose monohydrate, Anti-inflammatory drugs, Low-frequency Raman spectroscopy, Pharmaceutical analysis, Polyvinyl pyrrolidone, Raman spectroscopic, Solid dosage forms, Spatial analysis, Spectroscopic analysis",

author = "Ka̅rlis Be̅rziņ{\v s} and Fraser-Miller, {Sara J.} and Gordon, {Keith C.}",

year = "2021",

month = mar,

day = "2",

doi = "10.1021/acs.analchem.0c04960",

language = "English",

volume = "93",

pages = "3698--3705",

journal = "Analytical Chemistry",

issn = "0003-2700",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - A new frontier for nondestructive spatial analysis of pharmaceutical solid dosage forms:

T2 - Spatially offset low-frequency Raman spectroscopy

AU - Be̅rziņš, Ka̅rlis

AU - Fraser-Miller, Sara J.

AU - Gordon, Keith C.

PY - 2021/3/2

Y1 - 2021/3/2

N2 - A new Raman subtechnique, spatially offset low-frequency Raman spectroscopy (SOLFRS), is demonstrated via an analysis of pharmaceutical solid dosage forms. Several different model systems comprised of celecoxib (a popular anti-inflammatory drug), α-lactose anhydrous stable form, α-lactose monohydrate, and polyvinylpyrrolidone (PVP) were used to represent tangible scenarios for the application of SOLFRS. Additionally, the challenges and limitations were highlighted in relation to its real-time use, and potential solutions to address them were also provided. Lastly, the future directions for this new variation of Raman spectroscopic technique were briefly discussed, including its potential for broader application in pharmaceutical analysis and other research fields.

AB - A new Raman subtechnique, spatially offset low-frequency Raman spectroscopy (SOLFRS), is demonstrated via an analysis of pharmaceutical solid dosage forms. Several different model systems comprised of celecoxib (a popular anti-inflammatory drug), α-lactose anhydrous stable form, α-lactose monohydrate, and polyvinylpyrrolidone (PVP) were used to represent tangible scenarios for the application of SOLFRS. Additionally, the challenges and limitations were highlighted in relation to its real-time use, and potential solutions to address them were also provided. Lastly, the future directions for this new variation of Raman spectroscopic technique were briefly discussed, including its potential for broader application in pharmaceutical analysis and other research fields.

KW - Raman spectroscopy

KW - Sugars

KW - Alpha lactose monohydrate

KW - Anti-inflammatory drugs

KW - Low-frequency Raman spectroscopy

KW - Pharmaceutical analysis

KW - Polyvinyl pyrrolidone

KW - Raman spectroscopic

KW - Solid dosage forms

KW - Spatial analysis

KW - Spectroscopic analysis

U2 - 10.1021/acs.analchem.0c04960

DO - 10.1021/acs.analchem.0c04960

M3 - Article

SN - 0003-2700

VL - 93

SP - 3698

EP - 3705

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 8

ER -

A new frontier for nondestructive spatial analysis of pharmaceutical solid dosage forms: Spatially offset low-frequency Raman spectroscopy

Abstract

Keywords

Access to Document

Fingerprint

Cite this