A novel 3D micro-CT method for non-invasively assessing both bone loss and soft tissue swelling in a murine inflammatory arthritis model

Egon Perilli, Melissa Cantley, Victor Marino, Tania Crotti, Malcolm Smith, David Haynes, Anak Dharmapatni

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Rheumatoid arthritis (RA) is a chronic destructive inflammatory disease of the joints. The collagen antibody-induced arthritis (CAIA) mouse model provides a straightforward and rapid means of producing pathologies associated with inflammatory arthritis. However, regardless of the rodent model used to study the disease, current non-invasive read outs of disease severity, such as paw thickness/volume or clinical score grades, rely on assessment of edema, rather than on the underlying synovial proliferation, inflammatory cell infiltration, and osteoclastic bone resorption. To quantify the bone erosion in murine models of inflammatory arthritis, recent studies utilise micro-computed tomography (micro-CT).
Original languageEnglish
Pages69
Number of pages1
Publication statusPublished - 2013
EventAustralian & New Zealand Orthopaedic Research Society, 19th Annual Scientific Meeting - Sydney, Australia
Duration: 4 Sept 2013 → …

Conference

ConferenceAustralian & New Zealand Orthopaedic Research Society, 19th Annual Scientific Meeting
Country/TerritoryAustralia
CitySydney
Period4/09/13 → …

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