A novel 3D micro-CT method for non-invasively assessing both bone loss and soft tissue swelling in a murine inflammatory arthritis model

Egon Perilli, Melissa Cantley, Victor Marino, Tania Crotti, Malcolm Smith, David Haynes, Anak Dharmapatni

    Research output: Contribution to conferenceAbstractpeer-review

    Abstract

    Rheumatoid arthritis (RA) is a chronic destructive inflammatory disease of the joints. The collagen antibody-induced arthritis (CAIA) mouse model provides a straightforward and rapid means of producing pathologies associated with inflammatory arthritis. However, regardless of the rodent model used to study the disease, current non-invasive read outs of disease severity, such as paw thickness/volume or clinical score grades, rely on assessment of edema, rather than on the underlying synovial proliferation, inflammatory cell infiltration, and osteoclastic bone resorption. To quantify the bone erosion in murine models of inflammatory arthritis, recent studies utilise micro-computed tomography (micro-CT).
    Original languageEnglish
    Pages69
    Number of pages1
    Publication statusPublished - 2013
    EventAustralian & New Zealand Orthopaedic Research Society, 19th Annual Scientific Meeting - Sydney, Australia
    Duration: 4 Sep 2013 → …

    Conference

    ConferenceAustralian & New Zealand Orthopaedic Research Society, 19th Annual Scientific Meeting
    CountryAustralia
    CitySydney
    Period4/09/13 → …

    Fingerprint Dive into the research topics of 'A novel 3D micro-CT method for non-invasively assessing both bone loss and soft tissue swelling in a murine inflammatory arthritis model'. Together they form a unique fingerprint.

    Cite this