A novel antimicrobial agent reduces oxidative stress in cells

Eliza James, Helena Viola, Livia Hool, Paul Eggers, Colin Raston, Ramiz Boulos

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    1,3,5-Tris[(1E)-2′-(4″-benzoic acid)vinyl]benzene] (Ramizol™) is a potent and non-toxic synthetic antimicrobial agent, and we now establish that it is also a potent inhibitor of reactive oxygen species (ROS) generation, with similar antioxidant activity to α-tocopherol (Vitamin E), which is a standard antioxidant drug. The results show that Ramizol™ decreases ROS to basal levels in PC12 cells and mouse and guinea pig myocytes, and demonstrate its protective nature from oxidative damage to the cells. The continuing challenge to discover antibiotics with no or few side effects makes Ramizol™ a very attractive candidate for the potential treatment of infections.

    Original languageEnglish
    Pages (from-to)7277-7281
    Number of pages5
    JournalRSC Advances
    Volume3
    Issue number20
    DOIs
    Publication statusPublished - 2013

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  • Cite this

    James, E., Viola, H., Hool, L., Eggers, P., Raston, C., & Boulos, R. (2013). A novel antimicrobial agent reduces oxidative stress in cells. RSC Advances, 3(20), 7277-7281. https://doi.org/10.1039/c3ra40658j