A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL

O. G. Best; A. C. Gardiner; A. Majid; R. Walewska; B. Austen; A. Skowronska; R. Ibbotson; T. Stankovic; M. J. Dyer; D. G. Oscier

doi:10.1038/sj.leu.2405092

A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL

O. G. Best
, A. C. Gardiner
, A. Majid
, R. Walewska
, B. Austen
, A. Skowronska
, R. Ibbotson
, T. Stankovic
, M. J. Dyer
, D. G. Oscier

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Original language	English
Pages (from-to)	1456-1459
Number of pages	4
Journal	Leukemia
Volume	22
Issue number	7
DOIs	https://doi.org/10.1038/sj.leu.2405092
Publication status	Published - Jul 2008
Externally published	Yes

Bibliographical note

1476-5551 Best, O G Gardiner, A C Majid, A Walewska, R Austen, B Skowronska, A Ibbotson, R Stankovic, T Dyer, M J S Oscier, D G MC_U132670597/Medical Research Council/United Kingdom Letter England Leukemia. 2008 Jul;22(7):1456-9. doi: 10.1038/sj.leu.2405092. Epub 2008 Jan 17.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins/*genetics Cyclin-Dependent Kinase Inhibitor p21/genetics DNA-Binding Proteins/*genetics Etoposide/*administration & dosage *Genes, p53 Humans Imidazoles/*administration & dosage Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy/*genetics *Mutation Piperazines/*administration & dosage Protein-Serine-Threonine Kinases/*genetics Tumor Suppressor Proteins/*genetics

Access to Document

10.1038/sj.leu.2405092Licence: In Copyright

Cite this

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title = "A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL",

keywords = "Antineoplastic Combined Chemotherapy Protocols/*therapeutic use Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins/*genetics Cyclin-Dependent Kinase Inhibitor p21/genetics DNA-Binding Proteins/*genetics Etoposide/*administration \& dosage *Genes, p53 Humans Imidazoles/*administration \& dosage Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy/*genetics *Mutation Piperazines/*administration \& dosage Protein-Serine-Threonine Kinases/*genetics Tumor Suppressor Proteins/*genetics",

author = "Best, \{O. G.\} and Gardiner, \{A. C.\} and A. Majid and R. Walewska and B. Austen and A. Skowronska and R. Ibbotson and T. Stankovic and Dyer, \{M. J.\} and Oscier, \{D. G.\}",

note = "1476-5551 Best, O G Gardiner, A C Majid, A Walewska, R Austen, B Skowronska, A Ibbotson, R Stankovic, T Dyer, M J S Oscier, D G MC\_U132670597/Medical Research Council/United Kingdom Letter England Leukemia. 2008 Jul;22(7):1456-9. doi: 10.1038/sj.leu.2405092. Epub 2008 Jan 17.",

year = "2008",

month = jul,

doi = "10.1038/sj.leu.2405092",

language = "English",

volume = "22",

pages = "1456--1459",

journal = "Leukemia",

issn = "0887-6924",

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T1 - A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL

AU - Best, O. G.

AU - Gardiner, A. C.

AU - Majid, A.

AU - Walewska, R.

AU - Austen, B.

AU - Skowronska, A.

AU - Ibbotson, R.

AU - Stankovic, T.

AU - Dyer, M. J.

AU - Oscier, D. G.

N1 - 1476-5551 Best, O G Gardiner, A C Majid, A Walewska, R Austen, B Skowronska, A Ibbotson, R Stankovic, T Dyer, M J S Oscier, D G MC_U132670597/Medical Research Council/United Kingdom Letter England Leukemia. 2008 Jul;22(7):1456-9. doi: 10.1038/sj.leu.2405092. Epub 2008 Jan 17.

PY - 2008/7

Y1 - 2008/7

KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins/genetics Cyclin-Dependent Kinase Inhibitor p21/genetics DNA-Binding Proteins/genetics Etoposide/administration & dosage Genes, p53 Hu

U2 - 10.1038/sj.leu.2405092

DO - 10.1038/sj.leu.2405092

M3 - Article

SN - 0887-6924

VL - 22

SP - 1456

EP - 1459

JO - Leukemia

JF - Leukemia

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ER -