A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis

Hendrik Nel; Pascale Wehr; Christopher  Andoniou; Iona Schuster; Stephanie Gras; Helen McGuire; Helen Weedon; Annabelle Small; Katie Lowe; Mariapia Degli-Esposti; Mihir Wechalekar; Ranjeny Thomas

A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis

Hendrik Nel, Pascale Wehr, Christopher Andoniou, Iona Schuster, Stephanie Gras, Helen McGuire, Helen Weedon, Annabelle Small, Katie Lowe, Mariapia Degli-Esposti, Mihir Wechalekar, Ranjeny Thomas

College of Medicine and Public Health

Research output: Contribution to conference › Abstract › peer-review

Abstract

Background/Purpose: Rheumatoid Arthritis (RA) is associated with specific HLA-DR genotypes with an emphasis on the role of CD4+ effector-memory T cells (Tem) in disease pathogenesis. However, single cell sequencing technologies identified large numbers of CD8+ cytotoxic T lymphocytes (CTL) with distinct granzyme expression profiles infiltrating RA synovial tissue (ST) in active, established RA. Here we assessed T cell clonotypes in ST and peripheral blood (PB) of patients with recent-onset untreated RA and addressed the contribution of virus-specific CD8+ T cells to development of antigen-induced inflammatory arthritis

Original language	English
Number of pages	2
Publication status	Published - 2022
Event	American College of Rheumatology Convergence 2022 - Philadelphia, United States Duration: 10 Nov 2022 → 14 Nov 2022

Conference

Conference	American College of Rheumatology Convergence 2022
Abbreviated title	ACR Convergence 2022
Country/Territory	United States
City	Philadelphia
Period	10/11/22 → 14/11/22

Keywords

Cytotoxic cells
Mouse models
Rheumatoid arthritis
T cell

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https://acrabstracts.org/abstract/a-positive-feedback-model-for-the-contribution-of-virus-specific-t-cells-to-the-development-of-rheumatoid-arthritis/Licence: In Copyright

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Nel, H., Wehr, P., Andoniou, C., Schuster, I., Gras, S., McGuire, H., Weedon, H., Small, A., Lowe, K., Degli-Esposti, M., Wechalekar, M., & Thomas, R. (2022). A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis. Abstract from American College of Rheumatology Convergence 2022, Philadelphia, United States. https://acrabstracts.org/abstract/a-positive-feedback-model-for-the-contribution-of-virus-specific-t-cells-to-the-development-of-rheumatoid-arthritis/

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title = "A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis",

abstract = "Background/Purpose: Rheumatoid Arthritis (RA) is associated with specific HLA-DR genotypes with an emphasis on the role of CD4+ effector-memory T cells (Tem) in disease pathogenesis. However, single cell sequencing technologies identified large numbers of CD8+ cytotoxic T lymphocytes (CTL) with distinct granzyme expression profiles infiltrating RA synovial tissue (ST) in active, established RA. Here we assessed T cell clonotypes in ST and peripheral blood (PB) of patients with recent-onset untreated RA and addressed the contribution of virus-specific CD8+ T cells to development of antigen-induced inflammatory arthritis",

keywords = "Cytotoxic cells, Mouse models, Rheumatoid arthritis, T cell",

author = "Hendrik Nel and Pascale Wehr and Christopher Andoniou and Iona Schuster and Stephanie Gras and Helen McGuire and Helen Weedon and Annabelle Small and Katie Lowe and Mariapia Degli-Esposti and Mihir Wechalekar and Ranjeny Thomas",

year = "2022",

language = "English",

note = "American College of Rheumatology Convergence 2022, ACR Convergence 2022 ; Conference date: 10-11-2022 Through 14-11-2022",

}

Nel, H, Wehr, P, Andoniou, C, Schuster, I, Gras, S, McGuire, H, Weedon, H, Small, A, Lowe, K, Degli-Esposti, M, Wechalekar, M & Thomas, R 2022, 'A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis', American College of Rheumatology Convergence 2022, Philadelphia, United States, 10/11/22 - 14/11/22. <https://acrabstracts.org/abstract/a-positive-feedback-model-for-the-contribution-of-virus-specific-t-cells-to-the-development-of-rheumatoid-arthritis/>

TY - CONF

T1 - A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis

AU - Nel, Hendrik

AU - Wehr, Pascale

AU - Andoniou, Christopher

AU - Schuster, Iona

AU - Gras, Stephanie

AU - McGuire, Helen

AU - Weedon, Helen

AU - Small, Annabelle

AU - Lowe, Katie

AU - Degli-Esposti, Mariapia

AU - Wechalekar, Mihir

AU - Thomas, Ranjeny

PY - 2022

Y1 - 2022

N2 - Background/Purpose: Rheumatoid Arthritis (RA) is associated with specific HLA-DR genotypes with an emphasis on the role of CD4+ effector-memory T cells (Tem) in disease pathogenesis. However, single cell sequencing technologies identified large numbers of CD8+ cytotoxic T lymphocytes (CTL) with distinct granzyme expression profiles infiltrating RA synovial tissue (ST) in active, established RA. Here we assessed T cell clonotypes in ST and peripheral blood (PB) of patients with recent-onset untreated RA and addressed the contribution of virus-specific CD8+ T cells to development of antigen-induced inflammatory arthritis

AB - Background/Purpose: Rheumatoid Arthritis (RA) is associated with specific HLA-DR genotypes with an emphasis on the role of CD4+ effector-memory T cells (Tem) in disease pathogenesis. However, single cell sequencing technologies identified large numbers of CD8+ cytotoxic T lymphocytes (CTL) with distinct granzyme expression profiles infiltrating RA synovial tissue (ST) in active, established RA. Here we assessed T cell clonotypes in ST and peripheral blood (PB) of patients with recent-onset untreated RA and addressed the contribution of virus-specific CD8+ T cells to development of antigen-induced inflammatory arthritis

KW - Cytotoxic cells

KW - Mouse models

KW - Rheumatoid arthritis

KW - T cell

M3 - Abstract

T2 - American College of Rheumatology Convergence 2022

Y2 - 10 November 2022 through 14 November 2022

ER -

A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis

Abstract

Conference

Keywords

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