A proliferative defect of marrow cells in experimental chronic hypoplastic marrow failure (aplastic anaemia)

K. J. Trainor; A. A. Morley; R. S. Seshadri

A proliferative defect of marrow cells in experimental chronic hypoplastic marrow failure (aplastic anaemia)

K. J. Trainor, A. A. Morley, R. S. Seshadri

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Marrow cells from control mice and mice with chronic hypoplastic marrow failure (CHMF, aplastic anaemia) were grown in tissue culture and growth was assessed by measuring the number of cells/colony and uptake of ³H-thymidine/colony. Cells from mice with CHMF showed impaired proliferation in response to colony stimulating factor. Mixing experiments suggested that the impairment of proliferation was not due to alteration in suppressor or helper cells but to an intrinsic lesion of the marrow cells themselves.

Original language	English
Pages (from-to)	674-682
Number of pages	9
Journal	Experimental Hematology
Volume	8
Issue number	6
Publication status	Published - 1980

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Cite this

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title = "A proliferative defect of marrow cells in experimental chronic hypoplastic marrow failure (aplastic anaemia)",

abstract = "Marrow cells from control mice and mice with chronic hypoplastic marrow failure (CHMF, aplastic anaemia) were grown in tissue culture and growth was assessed by measuring the number of cells/colony and uptake of 3H-thymidine/colony. Cells from mice with CHMF showed impaired proliferation in response to colony stimulating factor. Mixing experiments suggested that the impairment of proliferation was not due to alteration in suppressor or helper cells but to an intrinsic lesion of the marrow cells themselves.",

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year = "1980",

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AU - Trainor, K. J.

AU - Morley, A. A.

AU - Seshadri, R. S.

PY - 1980

Y1 - 1980

N2 - Marrow cells from control mice and mice with chronic hypoplastic marrow failure (CHMF, aplastic anaemia) were grown in tissue culture and growth was assessed by measuring the number of cells/colony and uptake of 3H-thymidine/colony. Cells from mice with CHMF showed impaired proliferation in response to colony stimulating factor. Mixing experiments suggested that the impairment of proliferation was not due to alteration in suppressor or helper cells but to an intrinsic lesion of the marrow cells themselves.

AB - Marrow cells from control mice and mice with chronic hypoplastic marrow failure (CHMF, aplastic anaemia) were grown in tissue culture and growth was assessed by measuring the number of cells/colony and uptake of 3H-thymidine/colony. Cells from mice with CHMF showed impaired proliferation in response to colony stimulating factor. Mixing experiments suggested that the impairment of proliferation was not due to alteration in suppressor or helper cells but to an intrinsic lesion of the marrow cells themselves.

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M3 - Article

C2 - 6451444

AN - SCOPUS:0018852296

SN - 0301-472X

VL - 8

SP - 674

EP - 682

JO - Experimental Hematology

JF - Experimental Hematology

IS - 6

ER -

A proliferative defect of marrow cells in experimental chronic hypoplastic marrow failure (aplastic anaemia)

Abstract

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